Results 51 to 60 of about 510 (116)

Targets of tumor microenvironment for potential drug development

MedComm – Oncology, Volume 3, Issue 1, March 2024.
Here we review the potential targets of drugs according to the components of the tumor microenvironment (TME), including immune cells, stromal cells, and extracellular matrix (ECM) proteins, and further classify the key genes based on whether they function in direct or indirect way, to provide a comprehensive view of the current landscape of cancer ...
Ling Zhang, Ziruoyu Wang, Kailu Liu, Yihang Liu, Shuai Wang, Wei Jiang, Fanghui Lu, Yongjun Dang   +7 more
wiley   +1 more source

Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides

, 2006
Ab initio calculations (B3LYP/Lanl2DZ level of theory) were performed in this study to determine all the structural and catalytic zinc parameters required in order to study MMPs and their complexes with hydroxamate inhibitors by means of the AMBER force ...
MARTINELLI, ADRIANO, ROSSELLO, ARMANDO, NUTI, ELISA, TUCCINARDI, TIZIANO, UCCELLO BARRETTA, GLORIA, MURPHY G, BALZANO, FEDERICA, CARELLI P   +7 more
core   +1 more source

MMP-12 cleavage abolishes agrins capability to bind to laminin.

, 2012
(A) Dose-dependency of binding of miniagrin to laminin-coated plates indicates a specific interaction between full-length miniagrin with immobilized laminin. This interaction is abolished by MMP-12 processing of miniagrin.
Georgina Butler (136296), Christopher M. Overall (136307), Ainsley McFarlane (136301), Trushar R. Patel (136293), Irene Xie (136305), Jörg Stetefeld (136310)   +5 more
core   +1 more source

Molecular targets in the discovery and development of novel antimetastatic agents: current progress and future prospects [PDF]

, 2013
Tumour invasion and metastasis have been recognized as major causal factors in the morbidity and mortality among cancer patients. Many advances in the knowledge of cancer metastasis have yielded an impressive array of attractive drug targets, including ...
Stanslas, Johnson, Mohd Sidik, Shiran, Mei S Wong, Wong, Mei S., Johnson Stanslas, Rozi Mahmud, Shiran M Sidik, Mahmud, Rozi   +7 more
core   +1 more source

Gelatin zymography and the effect of tissue inhibitors of metalloproteinaseson the chloranil-induced shedding of dystroglycan.

, 2013
A. Primary astrocytes were incubated in the absence or the presenceof 25 µM chloranil for 7 h. Media samples were collected and analyzed by SDS-PAGE gelatin zymography. Note the clear bands against the blue background with an apparent molecular weight of
Sarah Stevenson (355059), Geoffroy Noël (355057), Hakima Moukhles (355060)   +2 more
core   +1 more source

Önemli ortak özellikleri tanımlamak amacıyla, bilinen mmp-9 enzim inhibitörleri üzerinde yapılan farmakofor modelleme çalışmaları

, 2020
Objective: In this study, pharmacophore models were generated to explain the structure–activity relationships by using the known MMP-9 inhibitors. Material and Method: Pharmacophore models were generated to explain the specification of the structure ...
Bolelli, Kayhan, Bolelli, Tuğba Ertan
core   +1 more source

Estudo de metaloproteases de Leishmania (Viannia) braziliensis pertencentes ao cromossomo 10 da família M8

, 2017
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.O genoma de Leishmania (Viannia) braziliensis possui um número significante de genes de metaloproteases.
Hammes, Amanda Sutter de Oliveira
core   +1 more source

Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors. [PDF]

Front Pharmacol, 2023
Clare RH, Dawson CA, Westhorpe A, Albulescu LO, Woodley CM, Mosallam N, Chong DJW, Kool J, Berry NG, O'Neill PM, Casewell NR.   +10 more
europepmc   +1 more source

Inhibiting Matrix Metalloproteinases Protects Evoked Electromyography Amplitudes and Muscle Tension in the Orbicularis Oris Muscle in a Rat Model of Facial Nerve Injury. [PDF]

J Neuropathol Exp Neurol, 2022
Wu S, Song L, Yu M, Gong C, Chen L.
europepmc   +1 more source

Stromal matrix metalloproteinase-9 (MMP-9) promotes pericyte recruitment in neuroblastoma angiogenesis : a new role for matrix metalloproteinases

, 2005
Neuroblastoma is a highly invasive neural crest derived cancer and the second most common solid tumor in children. Matrix metalloproteinases (MMPs) constitute a family of more than 26 endopeptidases that are able to proteolytically process a growing ...
Chantrain, Christophe F.
core