Results 51 to 60 of about 2,156 (171)

Matrix Metalloproteinases Contribute to the Calcification Phenotype in Pseudoxanthoma Elasticum

Biomolecules, 2023
Ectopic calcification and dysregulated extracellular matrix remodeling are prominent hallmarks of the complex heterogenous pathobiochemistry of pseudoxanthoma elasticum (PXE).
Ricarda Plümers, Christopher Lindenkamp, Michel Robin Osterhage, Cornelius Knabbe, Doris Hendig   +4 more
doaj   +1 more source

Efficacy and Limitations of Chemically Diverse Small-Molecule Enzyme-Inhibitors against the Synergistic Coagulotoxic Activities of Bitis Viper Venoms

Molecules, 2022
Snakebite remains a significant public health burden globally, disproportionately affecting low-income and impoverished regions of the world. Recently, researchers have begun to focus on the use of small-molecule inhibitors as potential candidates for ...
Nicholas J. Youngman, Matthew R. Lewin, Rebecca Carter, Arno Naude, Bryan G. Fry   +4 more
doaj   +1 more source

Reduced angiogenesis by marimastat in peritoneal dissemination model of gastric cancer

Gastroenterology, 2000
Norihito Wada, Yoshihide Otani, Tetsuro Kubota, Masaru Kimata, Akiko Minagawa, Koichiro Kumai, Kaori Kameyama, Yasunori Okada, Masaki Kitajima   +8 more
openalex   +2 more sources

LL-37 Inhibits TMPRSS2-Mediated S2' Site Cleavage and SARS-CoV-2 Infection but Not Omicron Variants. [PDF]

Cell Prolif
Cathelicidin LL‐37 inhibits SARS‐CoV‐2 by blocking the catalytic activity of TMPRSS2. The N764K mutation in the spike S2 subunit of Omicron variants confers resistance to LL‐37‐induced inhibition of TMPRSS2‐mediated S2' priming. ABSTRACT Continual evolution of SARS‐CoV‐2 spike drives the emergence of Omicron variants that show increased spreading and ...
Bi Z, Ren W, Zeng H, Zhou Y, Liu J, Chen Z, Zhang X, He X, Lu G, Wei Y, Wei X.   +10 more
europepmc   +2 more sources

Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms

Acta Pharmaceutica Sinica B, 2020
Repurposing small molecule drugs and drug candidates is considered as a promising approach to revolutionise the treatment of snakebite envenoming. In this study, we investigated the inhibiting effects of the small molecules varespladib (nonspecific ...
Chunfang Xie, Julien Slagboom, Laura-Oana Albulescu, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool   +6 more
doaj   +1 more source

Peripheral Arterial Thrombosis following Russell's Viper Bites

TH Open, 2023
Envenomings by Russell's viper (Daboia russelii), a species of high medical importance in India and other Asian countries, commonly result in hemorrhage, coagulopathies, necrosis, and acute kidney injury.
Subramanian Senthilkumaran, Ketan Patel, Elanchezhian Rajan, Pradeep Vijayakumar, Stephen W. Miller, Alexandra Rucavado, Soheil Gilabadi, Medha Sonavane, Nicholas J. Richards, Jarred Williams, Harry F. Williams, Steven A. Trim, Ponniah Thirumalaikolundusubramanian, José María Gutiérrez, Sakthivel Vaiyapuri   +14 more
doaj   +1 more source

Pictolysin-III, a Hemorrhagic Type-III Metalloproteinase Isolated from Bothrops pictus (Serpentes: Viperidae) Venom, Reduces Mitochondrial Respiration and Induces Cytokine Secretion in Epithelial and Stromal Cell Lines

Pharmaceutics, 2023
From the venom of the Bothrops pictus snake, an endemic species from Peru, we recently have described toxins that inhibited platelet aggregation and cancer cell migration.
Dan E. Vivas-Ruiz, Paola Rosas, Alex Proleón, Daniel Torrejón, Fanny Lazo, Ana Belén Tenorio-Ricca, Francisco Guajardo, Cristopher Almarza, Víctor Andrades, Jessica Astorga, Daniel Oropesa, Jorge Toledo, María Jesús Vera, Jorge Martínez, Ramiro Araya-Maturana, Karen Dubois-Camacho, Marcela A. Hermoso, Valéria G. Alvarenga, Eladio Flores Sanchez, Armando Yarlequé, Luciana Souza Oliveira, Félix A. Urra   +21 more
doaj   +1 more source

Melanoma Mediated Disruption of Brain Endothelial Barrier Integrity Is Not Prevented by the Inhibition of Matrix Metalloproteinases and Proteases

Biosensors, 2022
We have previously shown that human melanoma cells rapidly decrease human brain endothelial barrier strength. Our findings showed a fast mechanism of melanoma mediated barrier disruption, which was localised to the paracellular junctions of the brain ...
Akshata Anchan, Graeme Finlay, Catherine E. Angel, James J. W. Hucklesby, E. Scott Graham   +4 more
doaj   +1 more source

Clinical management of snakebite envenoming: Future perspectives

Toxicon: X, 2021
Snakebite envenoming is a major cause of morbidity and mortality in rural communities throughout the tropics. Generally, the main clinical features of snakebites are local swelling, tissue necrosis, shock, spontaneous systemic hemorrhage, incoagulable ...
Muhammad Hamza, Cecilie Knudsen, Christeine Ariaranee Gnanathasan, Wuelton Monteiro, Matthew R. Lewin, Andreas H. Laustsen, Abdulrazaq G. Habib   +6 more
doaj   +1 more source

Marimastat

Drugs in R & D, 2003
Marimastat [BB 2516, TA 2516] is a second-generation anticancer drug originally developed with British Biotech in Europe and North America. It is an orally active metalloprotease inhibitor of the same class as batimastat, and is the first compound in this class to have completed a pivotal clinical trial.
openaire   +2 more sources