Results 71 to 80 of about 2,156 (171)

“Locked” cancer cells are more sensitive to chemotherapy

Bioengineering & Translational Medicine, 2019
The treatment of metastatic cancer is a great challenging issue throughout the world. Conventional chemotherapy can kill the cancer cells and, whereas, would exacerbate the metastasis and induce drug resistance.
Yaqi Lyu, Qingqing Xiao, Yi Li, Yubing Wu, Wei He, Lifang Yin   +5 more
doaj   +1 more source

Systematic Exploration of Potential Druggable Genes for Ischemic Stroke Employing Genome‐Wide Mendelian Randomization Analysis

Brain and Behavior, Volume 15, Issue 9, September 2025.
This study identified six potential druggable genes (CALCRL, KCNJ11, NEK3, THSD1, MMP12, and HSD17B12) associated with ischemic stroke risk using a systematic druggable genome‐wide Mendelian randomization analysis. ABSTRACT Background Ischemic stroke (IS) treatment remains a significant challenge.
Peng Zhang, Yulu He, Qing Zhen, Yan Zhang   +3 more
wiley   +1 more source

The Urgent Need to Develop Novel Strategies for the Diagnosis and Treatment of Snakebites

Toxins, 2019
Snakebite envenoming (SBE) is a priority neglected tropical disease, which kills in excess of 100,000 people per year. Additionally, many millions of survivors also suffer through disabilities and long-term health consequences. The only treatment for SBE,
Harry F. Williams, Harry J. Layfield, Thomas Vallance, Ketan Patel, Andrew B. Bicknell, Steven A. Trim, Sakthivel Vaiyapuri   +6 more
doaj   +1 more source

Fibrotic Fortresses and Therapeutic Frontiers: Pancreatic Stellate Cells and the Extracellular Matrix in Pancreatic Cancer

Cancer Medicine, Volume 14, Issue 11, June 2025.
ABSTRACT Background Pancreatic ductal adenocarcinoma (PDAC) is characterized by a unique tumor microenvironment (TME) that plays pivotal roles in cancer progression, angiogenesis, metastasis, and drug resistance. This complex and dynamic ecosystem comprises cancer cells, stromal cells, and extracellular matrix (ECM) components, which interact ...
Sila Sigirli, Didem Karakas
wiley   +1 more source

Targeting angiogenesis for the treatment of advanced melanoma

Oncology Reviews, 2011
Metastatic melanoma (MM) carries a dismal prognosis, as it is largely resistant to conventional chemotherapy, bio-chemotherapy and immunotherapy. The search for new effective treatments is an unquestionable priority in MM.
Dimitrios J. Bafaloukos, Helena Linardou
doaj   +1 more source

Inhibition of Pseudomonas aeruginosa secreted virulence factors reduces lung inflammation in CF mice

Virulence, 2018
Background: Cystic fibrosis (CF) lung infection is a complex condition where opportunistic pathogens and defective immune system cooperate in developing a constant cycle of infection and inflammation.
Angela Sandri, Alessia Ortombina, Federico Boschi, Eleonora Cremonini, Marzia Boaretti, Claudio Sorio, Paola Melotti, Gabriella Bergamini, Maria Lleo   +8 more
doaj   +1 more source

Macrophage elastase (MMP-12): a pro-inflammatory mediator?

Memorias do Instituto Oswaldo Cruz, 2005
As many metalloproteinases (MMPs), macrophage elastase (MMP-12) is able to degrade extracellular matrix components such as elastin and is involved in tissue remodeling processes.
Soazig Nénan, Elisabeth Boichot, Vincent Lagente, Claude P Bertrand   +3 more
doaj   +1 more source

Altered O‐glycosylation of β1‐adrenergic receptor N‐terminal single‐nucleotide variants modulates receptor processing and functional activity

The FEBS Journal, Volume 292, Issue 5, Page 998-1018, March 2025.
The human β1‐adrenergic receptor (β1AR) carries common (S49G) and rare (R31Q, A29T) single‐nucleotide polymorphisms (SNPs) in its extracellular N‐terminal domain. These were found to alter receptor O‐glycosylation and/or proteolytic cleavage, resulting in SNP‐dependent differences in β1AR cell surface expression and function that also involved the ...
Hanna E. Tuhkanen, Ilona J. Haasiomäki, Jarkko J. Lackman, Christoffer K. Goth, S. Orvokki Mattila, Zilu Ye, Sergey Y. Vakhrushev, Johanna Magga, Risto Kerkelä, Henrik Clausen, Katrine T. Schjoldager, Ulla E. Petäjä‐Repo   +11 more
wiley   +1 more source

Data from Novel Matrix Metalloproteinase Inhibitor [¹⁸F]Marimastat-Aryltrifluoroborate as a Probe for <i>In vivo</i> Positron Emission Tomography Imaging in Cancer

, 2023
Ulrich auf dem Keller, Caroline L. Bellac, Ying Li, Yuanmei Lou, Philipp F. Lange, Richard Ting, Curtis Harwig, Reinhild Kappelhoff, Shoukat Dedhar, Michael J. Adam, Thomas J. Ruth, François Bénard, David M. Perrin, Christopher M. Overall   +13 more
openalex   +2 more sources

System biology approach to identify the novel biomarkers in glioblastoma multiforme tumors by using computational analysis

Frontiers in Pharmacology
Introduction: The most common primary brain tumor in adults is glioblastoma multiforme (GBM), accounting for 45.2% of all cases. The characteristics of GBM, a highly aggressive brain tumor, include rapid cell division and a propensity for necrosis ...
Safar M. Alqahtani, Ali Altharawi, Alhumaidi Alabbas, Faisal Ahmad, Faisal Ahmad, Hassan Ayaz, Asia Nawaz, Sidra Rahman, Manal A. Alossaimi   +8 more
doaj   +1 more source