Results 91 to 100 of about 2,105 (188)

Inhibition of Pseudomonas aeruginosa secreted virulence factors reduces lung inflammation in CF mice

Virulence, 2018
Background: Cystic fibrosis (CF) lung infection is a complex condition where opportunistic pathogens and defective immune system cooperate in developing a constant cycle of infection and inflammation.
Angela Sandri, Alessia Ortombina, Federico Boschi, Eleonora Cremonini, Marzia Boaretti, Claudio Sorio, Paola Melotti, Gabriella Bergamini, Maria Lleo   +8 more
doaj   +1 more source

Can metal complexes serve as hypoxia activated prodrugs? Investigations of a Co(III) complex of the MMP inhibitor marimastat

, 2003
For many years proof that the hypoxic nature of malignant tumours can be used to selectively target anticancer drugs has been sought. Several classes of potential redox activated anticancer drugs have been developed to take advantage of the reducing ...
Cullinane, C. M., Hambley, T. W., Failes, T. W., Diakos, C. I., Lyons, J. G., Underwood, C. K.   +5 more
core   +1 more source

Marimastat reversed hepatic steatosis and improved surrogate markers for insulin sensitivity in diet-induced obese mice as well as in ob/ob animals.

, 2013
Mean hepatic fat fraction as measured by MR spectroscopy was decreased following Marimastat treatment (A). Marimastat treatment resulted in a decrease of plasma alanine aminotransferase levels (B), indicating decreased hepatic injury.
Hau D. Le (343378), Vincent E. de Meijer (343377), Yury Popov (343381), Anisha K. Sharma (343380), Mark Puder (343382), Jonathan A. Meisel (343379)   +5 more
core   +1 more source

An in vitro model that can distinguish between effects on angiogenesis and on established vasculature: Actions of TNP-470, marimastat and the tubulin-binding agent Ang-510

, 2010
In anti-cancer therapy, current investigations explore the possibility of two different strategies to target tumor vasculature: one aims at interfering with angiogenesis, the process involving the outgrowth of new blood vessels from pre-existing vessels,
Bloys, H., Wijngaarden, J. van, Beek, E. van, van Hinsbergh, V.W.M., Lowik, C.W.G.M., van Beek, E., van Wijngaarden, J., Snoeks, T.J.A., Kaijzel, E.L., Hinsbergh, V.W.M. van   +9 more
core   +1 more source

p53 modeling as a route to mesothelioma patients stratification and novel therapeutic identification

Journal of Translational Medicine, 2018
Background Malignant pleural mesothelioma (MPM) is an orphan disease that is difficult to treat using traditional chemotherapy, an approach which has been effective in other types of cancer.
Kun Tian, Emyr Bakker, Michelle Hussain, Alice Guazzelli, Hasen Alhebshi, Parisa Meysami, Constantinos Demonacos, Jean-Marc Schwartz, Luciano Mutti, Marija Krstic-Demonacos   +9 more
doaj   +1 more source

Incorporation of Bulky and Cationic Cyclam-Triazole Moieties into Marimastat Can Generate Potent MMP Inhibitory Activity without Inducing Cytotoxicity.

, 2013
The synthesis and matrix metalloproteinase (MMP) inhibitory activity of a cyclam-marimastat conjugate and its metal complexes are described. The conjugate, synthesized with a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition ("click" reaction ...
Yu, M, Nagase, H, Lim, Ngee Han, Triccas, JA, Lim, NH, Rutledge, PJ, Ellis, S, Todd, MH, Nagase, Hideaki   +8 more
core   +1 more source

Effects of Marimastat on serum adipokine levels, fatty acid export from the liver and TACE activity.

, 2013
C57BL/6 animals were fed a high fat diet for 9 weeks, followed by two weeks of treatment with either Marimastat (MAR) or vehicle (VEH) control. Ob/ob animals were fed a normal fat diet and received 4 weeks of MAR or VEH control.
Hau D. Le (343378), Vincent E. de Meijer (343377), Yury Popov (343381), Anisha K. Sharma (343380), Mark Puder (343382), Jonathan A. Meisel (343379)   +5 more
core   +1 more source

Inside a Metastatic Fracture: Molecular Bases and New Potential Therapeutic Targets

Cancer Medicine
Introduction Bone metastases and pathological fractures significantly impact the prognosis and quality of life in cancer patients. However, clinical and radiological features alone have been shown to fail to predict skeletal related events of a bone ...
Alessandro Bruschi, Andrea Sambri, Michele Fiore, Elisa Bubbico, Cristina Scollo, Andrea Pace, Renato Zunarelli, Andrea Montanari, Alberta Cappelli, Lorenzo Di Prinzio, Massimiliano De Paolis   +10 more
doaj   +1 more source

Marimastat inhibits elastin degradation and matrix metalloproteinase 2 activity in a model of aneurysm disease

Journal of British Surgery, 1999
Abstract Background Abdominal aortic aneurysms are characterized by degradation of the extracellular matrix, with a reduction in the elastin concentration of the arterial media. These changes have been linked to increased levels of endogenous metalloproteinases (MMPs) within the aorta, particularly ...
G D, Treharne, J R, Boyle, S, Goodall, I M, Loftus, P R, Bell, M M, Thompson   +5 more
openaire   +2 more sources

Effects of AB0041 on rat joints.

, 2015
(A) Assessment of AB0041 (50 mg/kg, twice daily) and marimastat (5.5–7 mg/kg/day) in an MSS model: Mean total disease scores (+/- SD) of rats treated with AB0041, marimastat, or vehicle are shown.
Christopher O’Sullivan (456385), Derek C. Marshall (736936), Brett Jorgensen (736945), Chian Liu (736940), Haben Ghermazien (736942), Carlos A. Garcia (736944), Michael Lee (353518), Rhyannon Spangler (736939), Scott McCauley (736937), Amanda Mikels-Vigdal (736943), Arleene C. Velayo (736946), Victoria Smith (493351), Maria Kovalenko (736938), Joanne I. Adamkewicz (228601), Ruth Wang (736947), Susan K. Lyman (228597), Vivian Barry-Hamilton (736941)   +16 more
core   +1 more source