Results 61 to 70 of about 2,081,349 (273)

Chemical Structures, Toxicology, and Biogenetic Origins of Marine Toxins Occurring in Lipid Fractions of Marine Fish and Shellfish.

Journal of Japan Oil Chemists' Society, 1997
魚介類の脂質区に出現する有毒成分は関与する中毒のタイプによって, 下痢性貝毒, 神経性貝毒, シガテラ魚類中毒に3分される。下痢性貝毒の主要成分のオカダ酸とその類縁体は渦鞭毛藻のDinophysis fortiiによって生産され, タンパク脱リン酸酵素2A型を阻害し, 強力な発がん促進物質である。神経性貝毒は渦鞭毛藻 Gymnodinium breveを起源とし, エーテル環がはしご状に連結した骨格を特徴とする。シガテラ原因毒のシガトキシン類は渦鞭毛藻Gambierdiscus toxicusを起源とし, 同じくはしご状のエーテル環骨格を有する。神経性貝毒とシガテラ毒は電位依存性のナトリウムチャンネルを活性化する。いずれの毒も高度に酸化され, 強力な毒性を有し, 分子量が大きい ...
openaire   +2 more sources

Deep Learning Network‐Tailored Microenvironment Matching of 4D Bioprinting Bioactive Scaffolds for Bone Regeneration

Advanced Science, EarlyView.
A DLN dataset was built to analyze MABS composition versus in vitro/in vivo osteogenesis and angiogenesis. An MLP neural network, taking BG morphological parameters as input, extracts bioactive features from these datasets. A rabbit tibial defect model then validates 4D‐printed MABS for adaptability and bone regeneration in critical defects.
Xiongjie Liang, Yuechi Zhang, Weifeng Hu, Shiyan Lv, Fan Jia, Yan Zhang, Feng Wu, Changjiang Yang, Guanqi Zhen, Jinglong Yan, Xu Cui, Wei Zhao, Guanghua Chen   +12 more
wiley   +1 more source

Microwave-assisted synthesis of bis-(N,N-dialkyl)/O-aryl N,N-dialkyl-2-(1- methyl/ phenyl-2-oxopropylidene) phosphorohydrazido oximes on a solid support under solvent free conditions: Marine fish toxin analogues

Phosphorus, Sulfur, and Silicon and the Related Elements, 2017
A simple and efficient method has been developed for the synthesis of marine fish toxin derivatives bis-(N,N-dialkyl)/O-aryl N,N-dialkyl-2-(1-methyl/phenyl-2-oxopropylidene) phosphorohydrazido oximes from their corresponding hydrazides by using magnesium sulfate as a solid support under microwave irradiation.
Kumari, Nisha, Vyas, Naresh, A. K. Gupta
openaire   +2 more sources

Industry-led awards 2018. Marine Institute Grant Awards in Support of the Marine Economy. [PDF]

, 2019
Innovation 2020, Ireland’s strategy for research and development, science and technology states that despite the importance of research and innovation for firms, firms under-invest in research.
Marine Institute
core   +1 more source

Metagenomic Association Uncovers Host Genotype‐Structured Rhizobacterial Networks and Novel Taxa That Enhance Soybean Salt Tolerance

Advanced Science, EarlyView.
An STI‐guided metagenomic association framework links soybean salt‐tolerance phenotypes with rhizosphere microbiome composition and network organization in natural saline soils. The approach identifies candidate beneficial taxa, including Thalassospira xiamenensis, and provides an efficient strategy for mining stress‐protective microbes from native ...
Yu Luo, Feng‐Li Kang, Qi‐Min Li, Wei‐Cai Yang   +3 more
wiley   +1 more source

Sequence analysis of the cDNA encoding for SpCTx: a lethal factor from scorpionfish venom (Scorpaena plumieri)

Journal of Venomous Animals and Toxins including Tropical Diseases, 2018
Background Lethal factors are multifunctional oligomeric proteins found in the venomous apparatus of Scorpaeniformes fish. These toxins elicit not only an array of biological responses in vitro but also cardiovascular disorders and strong hemolytic ...
Fábio L. S. Costa, Maria Elena De Lima, Suely G. Figueiredo, Rafaela S. Ferreira, Núbia S. Prates, Tetsu Sakamoto, Carlos E. Salas   +6 more
doaj   +1 more source

Ciguatera Fish Poisoning in the Caribbean Sea and Atlantic Ocean: Reconciling the Multiplicity of Ciguatoxins and Analytical Chemistry Approach for Public Health Safety

Toxins, 2023
Ciguatera is a major circumtropical poisoning caused by the consumption of marine fish and invertebrates contaminated with ciguatoxins (CTXs): neurotoxins produced by endemic and benthic dinoflagellates which are biotransformed in the fish food-web.
Ivannah Pottier, Richard J. Lewis, Jean-Paul Vernoux   +2 more
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

First Detection of Algal Caribbean Ciguatoxin in Amberjack Causing Ciguatera Poisoning in the Canary Islands (Spain)

Toxins
Ciguatera Poisoning (CP) is an illness associated with the consumption of fish contaminated with potent natural toxins found in the marine environment, commonly known as ciguatoxins (CTXs).
Pablo Estevez, Juan Oses-Prieto, David Castro, Alejandro Penin, Alma Burlingame, Ana Gago-Martinez   +5 more
doaj   +1 more source

PHARMACOLOGICAL ACTIONS OF THE MARINE TOXINS CIGUATOXIN AND MAITOTOXIN ISOLATED FROM POISONOUS FISH

The Biological Bulletin, 1987
Ciguatoxin and maitotoxin isolated from poisonous fish and toxic dinoflagellates exhibited a powerful excitatory effect on smooth and cardiac muscle. The ciguatoxin-induced excitatory action is due to an increase in Na+ permeability of tetrodotoxin sensitive Na channels, while the maitotoxin-induced excitatory effect is caused by an increased Ca2 ...
openaire   +3 more sources