Results 71 to 80 of about 30,588 (282)

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

First Detection of Algal Caribbean Ciguatoxin in Amberjack Causing Ciguatera Poisoning in the Canary Islands (Spain)

Toxins
Ciguatera Poisoning (CP) is an illness associated with the consumption of fish contaminated with potent natural toxins found in the marine environment, commonly known as ciguatoxins (CTXs).
Pablo Estevez, Juan Oses-Prieto, David Castro, Alejandro Penin, Alma Burlingame, Ana Gago-Martinez   +5 more
doaj   +1 more source

Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins. [PDF]

, 2019
Dinoflagelates and cyanobacteria produce saxitoxin (STX), a lethal bis-guanidinium neurotoxin causing paralytic shellfish poisoning. A number of metazoans have soluble STX-binding proteins that may prevent STX intoxication.
Du Bois, J, Lolicato, Marco, Minor, Daniel L, Thomas-Tran, Rhiannon, Yen, Tien-Jui   +4 more
core   +2 more sources

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

Effects of the harmful algal bloom toxin, okadaic acid, on the mechanoreceptors of larval anchoveta (Engraulis ringens) under varying environmental conditions

Frontiers in Marine Science
The effect of the combination of marine toxins produced by algal blooms, in conjunction with varying environmental characteristics on organisms in the water column, is a poorly explored research field.
Piera Pepe-Vargas, Piera Pepe-Vargas, Piera Pepe-Vargas, Leonardo R. Castro, Catharina Alves-de-Souza, Alejandra Llanos-Rivera   +5 more
doaj   +1 more source

Sustainable Phosphorylated Cellulose Nanocrystals: A Dual‐Affinity Platform for High‐Efficiency Enrichment of Intact Glycopeptides and Phosphopeptides

Advanced Science, EarlyView.
AAA ABSTRACT Protein glycosylation and phosphorylation are critical post‐translational modifications (PTMs) governing nearly all cellular functions, yet their analysis remains challenging due to reliance on costly and unsustainable enrichment materials.
Jiaying Li, Wuming Fan, Xuyang Yue, Dongdong Wang, Xiangyu Tang, Zhuo Zhang, Yonggui Wang, Yanjun Xie, Mingliang Ye, Hongqiang Qin   +9 more
wiley   +1 more source

PICES Press, Vol. 20, No. 2, Summer 2012 [PDF]

, 2012
•The 2012 Inter-sessional Science Board Meeting: A Note from Science Board Chairman (pp. 1-4) ◾PICES Interns (p. 4) ◾2012 Inter-sessional Workshop on a Roadmap for FUTURE (pp. 5-8) ◾Second Symposium on “Effects of Climate Change on the World’s Oceans”

core  

Microwave-assisted synthesis of bis-(N,N-dialkyl)/O-aryl N,N-dialkyl-2-(1- methyl/ phenyl-2-oxopropylidene) phosphorohydrazido oximes on a solid support under solvent free conditions: Marine fish toxin analogues

Phosphorus, Sulfur, and Silicon and the Related Elements, 2017
A simple and efficient method has been developed for the synthesis of marine fish toxin derivatives bis-(N,N-dialkyl)/O-aryl N,N-dialkyl-2-(1-methyl/phenyl-2-oxopropylidene) phosphorohydrazido oximes from their corresponding hydrazides by using magnesium sulfate as a solid support under microwave irradiation.
Kumari, Nisha, Vyas, Naresh, A. K. Gupta
openaire   +1 more source

Mechanically Robust Biodegradable Stents With Theragenerative Vascular Responses via Combined 3D Printing and Janus Nanoengineering

Advanced Science, EarlyView.
This work introduces a theragenerative 3D‐printed biodegradable stent with Janus nanoarchitecture for spatially controlled vascular healing. A luminal tantalum ion–implanted surface accelerates endothelialization and hemocompatibility, while an abluminal sirolimus/poly‐L‐lactic acid–tantalum layer provides sustained drug release and suppresses smooth ...
Jong Hwa Seo, Dong‐Sung Won, Hyun Lee, Seojoon Bang, Hyeong Seok Kang, Ju Yeong Gwon, Chan Ho Moon, Ji Won Kim, Yubeen Park, Minho Kang, Dong Yun Lee, Donghyun Lim, Kisuk Yang, Gi Doo Cha, Soo‐Hong Lee, Tae‐Sik Jang, Seokbeom Kim, Jun‐Kyu Park, Jung‐Hoon Park, Hyun‐Do Jung   +19 more
wiley   +1 more source

Okadaic Acid: More than a Diarrheic Toxin

Marine Drugs, 2013
Okadaic acid (OA) is one of the most frequent and worldwide distributed marine toxins. It is easily accumulated by shellfish, mainly bivalve mollusks and fish, and, subsequently, can be consumed by humans causing alimentary intoxications.
Josefina Méndez, Blanca Laffon, María Verónica Prego-Faraldo, Eduardo Pásaro, Vanessa Valdiglesias   +4 more
doaj   +1 more source