Results 41 to 50 of about 3,588,226 (297)
A method to optimize selection on multiple identified quantitative trait loci
Genetics Selection Evolution, 2002 A mathematical approach was developed to model and optimize selection on multiple known quantitative trait loci (QTL) and polygenic estimated breeding values in order to maximize a weighted sum of responses to selection over multiple generations.
Dekkers Jack CM +2 more
doaj +1 more source
BMC Plant Biology, 2023 Background Crop biofortification is a successful strategy to ameliorate Vitamin A deficiency. Sorghum is a good candidate for vitamin A biofortification, as it is a staple food in regions with high prevalence of vitamin A deficiency.
Clara Cruet-Burgos +2 more
doaj +1 more source
Response to mass selection when an identified major gene is segregating [PDF]
, 1998 A deterministic model to predict response with mass selection when a major locus is segregating is presented. The model uses a selection index framework in which the weight of the different components included in the index are adjusted to describe the ...
Ricardo Pong-Wong +4 more
core +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Genetics Selection Evolution, 2004 A method was developed to optimize simultaneous selection for a quantitative trait with a known QTL within a male and a female line to maximize crossbred performance from a two-way cross. Strategies to maximize cumulative discounted response in crossbred
Chakraborty Reena, Dekkers Jack CM
doaj +1 more source
Horticulturae, 2022 Molecular marker-assisted gene pyramiding combined with backcrossing has been widely applied for crop variety improvement. Molecular marker identification could be used in the early stage of breeding to achieve the rapid and effective pyramiding of ...
Jingyi Zheng +6 more
doaj +1 more source
Potential benefit from using an identified major gene in BLUP evaluation with truncation and optimal selection [PDF]
, 1999 This study investigates the benefit of including information on an identified major gene in the estimation of breeding values in BLUP selection programmes. Selection for a quantitative trait is controlled by polygenes and a major locus with known effect.
Ricardo Pong-Wong +11 more
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
G3: Genes, Genomes, Genetics, 2017 Soil-borne pathogens of the Pacific Northwest decrease yields in both spring and winter wheat. Pathogens of economic importance include Fusarium culmorum, Pratylenchus neglectus, P. thornei, and Rhizoctonia solani AG8.
Alison L. Thompson +5 more
doaj +1 more source