Results 51 to 60 of about 270,162 (309)

Future trends in Animal Breeding due to new genetic tecnologies

, 2011
The Darwin theory of evolution by natural selection is based on three principles: (a) variation; (b) inheritance; and (c) natural selection. Here, I take these principles as an excuse to review some topics related to the future research prospects in ...
Toro Ibañez, Miguel Angel
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Tagging Quantitative Trait Loci for Maturity-Corrected Late Blight Resistance in Tetraploid Potato with PCR-Based Candidate Gene Markers

Molecular Plant-Microbe Interactions, 2004
Late blight caused by the oomycete Phytophthora infestans is the economically most important and destructive disease in potato cultivation. Quantitative resistance to late blight available in tetraploid cultivars is correlated with late maturity in ...
Christina Angelika Bormann, Andreas Marcus Rickert, Rosa Angela Castillo Ruiz, Jürgen Paal, Jens Lübeck, Josef Strahwald, Karsten Buhr, Christiane Gebhardt   +7 more
doaj   +1 more source

Genetic linkage mapping of economically important traits in cultivated tetraploid potato (Solanum tuberosum L.) [PDF]

, 2015
The objective of this study was to construct a single nucleotide polymorphism (SNP)-based genetic map at the cultivated tetraploid level to locate quantitative trait loci (QTL) contributing to economically important traits in potato (Solanum tuberosum L.)
Bormann, Bradshaw, Cleveland, De Jong, Douches, Douches, Douches, Driscoll, Felcher, Foster, Gebhardt, Gebhardt, Grunwald, Hackett, Hackett, Hackett, Hamilton, Hein, Hirsch, Hirsch, Huang, Jelihovschi, Jo, Jo, Jupe, Kirk, Kloosterman, Li, Li, Luo, Nelson, Nettleton, Pel, Ramakrishnan, Rezvoy, Rietman, Rojas, Schwarz, Scott, Sharma, Smilde, Tan, Tiwari, Vleeshouwers, Voorrips, Vossen, Young, Zhang   +47 more
core   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Estimation of linkage disequilibrium in four US pig breeds

BMC Genomics, 2012
Background The success of marker assisted selection depends on the amount of linkage disequilibrium (LD) across the genome. To implement marker assisted selection in the swine breeding industry, information about extent and degree of LD is essential. The
Badke Yvonne M, Bates Ronald O, Ernst Catherine W, Schwab Clint, Steibel Juan P   +4 more
doaj   +1 more source

Detection of growth-related QTLs in turbot (Scophtalmus maximux) [PDF]

, 2011
Background The turbot (Scophthalmus maximus) is a highly appreciated European aquaculture species. Growth related traits constitute the main goal of the ongoing genetic breeding programs of this species. The recent construction of a consensus linkage map
Bouza, Carmen, Cabaleiro, Santiago, Cerna, Alex, Fernandez, Jesus, Hermida, Miguel, Martinez, Paulino, Pardo, Belen G., Sanchez Molano, Enrique, Toro Ibañez, Miguel Angel   +8 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Development of two sequence-specific PCR markers linked to the le gene that reduces pod shattering in narrow-leafed Lupin (Lupinus angustifolius L.)

Genetics and Molecular Biology, 2007
Wild types of narrow-leaf lupin (Lupinus angustifolius L.) have seed pods that shatter upon maturity, leading to the loss of their seeds before or during the harvest process.
Jeffrey G. Boersma, Bevan J. Buirchell, Krishnapillai Sivasithamparam, Huaan Yang   +3 more
doaj   +1 more source