Results 11 to 20 of about 6,228,391 (354)

Circulating Tumor Cell PD-L1 Expression as Biomarker for Therapeutic Efficacy of Immune Checkpoint Inhibition in NSCLC

open access: yesCells, 2019
Over the last decade, the immune checkpoint blockade targeting the programmed death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) axis has improved progression-free and overall survival of advanced non-small cell lung cancer (NSCLC) patients.
Vera Kloten   +3 more
doaj   +1 more source

N-Terminally Truncated and Pyroglutamate-Modified Aβ Forms Are Measurable in Human Cerebrospinal Fluid and Are Potential Markers of Disease Progression in Alzheimer’s Disease

open access: yesFrontiers in Neuroscience, 2021
Alzheimer’s disease (AD) is a pathology characterized by the accumulation in the brain of intracellular and extracellular amyloid-β (Aβ) aggregates, especially of Aβ1–40 and Aβ1–42 peptides.
Guido Domingo   +11 more
doaj   +1 more source

Humor Markers [PDF]

open access: yes, 2017
In 1899, French poet Alcanter de Brahm proposed that ironists should use a specific punctuation mark known as the ironic sign to guide their readers explicitly in an ironic interpretation of an utterance. The irony mark would be a spoiler alert, and thereby reduce the pleasure of using irony. In order to help the receiver to detect the intention of the
Burgers, C., van Mulken, M.
openaire   +4 more sources

Inference of population structure using multilocus genotype data: dominant markers and null alleles

open access: yesMolecular Ecology Notes, 2007
Dominant markers such as amplified fragment length polymorphisms (AFLPs) provide an economical way of surveying variation at many loci. However, the uncertainty about the underlying genotypes presents a problem for statistical analysis.
D. Falush, M. Stephens, J. Pritchard
semanticscholar   +1 more source

Molecular Pathways Bridging Frontotemporal Lobar Degeneration and Psychiatric Disorders

open access: yesFrontiers in Aging Neuroscience, 2016
The overlap of symptoms between neurodegenerative and psychiatric diseases has been reported. Neuropsychiatric alterations are commonly observed in dementia, especially in the behavioral variant of frontotemporal dementia (bvFTD), which is the most ...
Roberta eZanardini   +3 more
doaj   +1 more source

Variable number of tandem repeat markers in the genome sequence of Mycosphaerella fijiensis, the causal agent of black leaf streak disease of banana (Musa spp) [PDF]

open access: yes, 2010
. We searched the genome of Mycosphaerella fijiensis for molecular markers that would allow population genetics analysis of this plant pathogen. M. fijiensis, the causal agent of banana leaf streak disease, also known as black Sigatoka, is the most ...
Ferreira, C.F.   +8 more
core   +4 more sources

MDSC: Markers, development, states, and unaddressed complexity.

open access: yesImmunity, 2021
Myeloid-derived suppressor cells (MDSCs) are one of the most discussed biological entities in immunology. While the context and classification of this group of cells has evolved, MDSCs most commonly describe cells arising during chronic inflammation ...
Samarth Hegde, A. Leader, M. Merad
semanticscholar   +1 more source

Cerebrospinal Fluid EV Concentration and Size Are Altered in Alzheimer’s Disease and Dementia with Lewy Bodies

open access: yesCells, 2022
Alzheimer’s disease (AD), dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD) represent the three major neurodegenerative dementias characterized by abnormal brain protein accumulation. In this study, we investigated extracellular vesicles (
Antonio Longobardi   +12 more
doaj   +1 more source

A new and versatile method for the successful conversion of AFLP-TM markers into simple single locus markers [PDF]

open access: yes, 2003
Genetic markers can efficiently be obtained by using amplified fragment length polymorphism (AFLP) fingerprinting because no prior information on DNA sequence is required.
Brugmans, B.W.   +4 more
core   +2 more sources

Imaging Markers in Genetic Forms of Parkinson’s Disease

open access: yesBrain Sciences, 2023
Parkinson’s disease (PD) is a complex neurodegenerative disorder characterized by motor symptoms such as bradykinesia, rigidity, and resting tremor.
Amgad Droby, Avner Thaler, Anat Mirelman
doaj   +1 more source

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