Results 41 to 50 of about 4,176,858 (401)

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Efectos de la promoción de ventas en el largo plazo en Marcas de Fabricante y Marcas de Distribución en la categoría de bebidas energéticas

AD Research, 2010
En esta investigación los autores analizan los diferentes tipos de promoción utilizados tanto por Marcas de Fabricante como por Marcas de Distribución y los efectos producidos en el largo plazo en las ventas en una y otra categoría.
Julio Alard Josemaría, Cristina Marín Palacios, José María Cubillo Pinilla   +2 more
doaj   +1 more source

A market

, 2020
This chapter, unlike in the previous one, assumes that the ownership of a house is recognized and protected. Each house is initially owned by some individual. Houses can be exchanged only with the mutual consent of both owners; no individual can force another individual to give up her house.
Martin J. Osborne, Ariel Rubinstein
openaire   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Digital Signage: An Experience of Innovation in Higher Education

Multidisciplinary Journal for Education, Social and Technological Sciences, 2015
This project on teaching innovation was developed in ESIC Business & Marketing School Valencia and is based on the educational opportunities provided by Digital Signage.
Vanessa Roger-Monzó, María Guijarro-García, Myriam Martí-Sánchez   +2 more
doaj   +1 more source

Relevance of Kappa and Lambda Free Light Chains in Autoimmune Astrocytopathy Associated With Anti‐GFAP Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction The kappa‐free light chain (κ‐FLC) index is known to be highly sensitive and specific for diagnosing multiple sclerosis (MS), while little is understood about lambda (λ)‐FLC. This study assessed the κ‐FLC and λ‐FLC indices in autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy.
Michael Levraut, Romain Marignier, Mikael Cohen, Jeanne Benoit, Cassandre Landes‐Chateau, Elisabeth Maillart, Marion Cremoni, Barbara Seitz‐Polski, Anne‐Laurie Pinto, Pauline Dumez, Jérôme Honnorat, Christine Lebrun‐Frenay   +11 more
wiley   +1 more source

Beyond Reality: Investigating the Power of Scarcity and Rarity on Consumer Attitudes in Metaverse Fashion Retail

Human Behavior and Emerging Technologies
This research explores consumer attitudes and behavior in a metaverse retailing environment, mainly focusing on how perceptions of scarcity and rarity influence consumers’ views of purchasing virtual wearables.
Claudio Schapsis, Petru Micu, Nikki Wingate   +2 more
doaj   +1 more source

Analysis of the perception of usefulness in students and teachers about the use of Moodle in the EHEA

Red U, 2019
This study analyzes the perception of teachers and university students of the usefulness of learning management systems (LMS) in which five dimensions of the usefulness of the Moodle platform usefulness are investigated: “content”, “activities ...
M.P. Llopis-Amorós, V. Roger-Monzó, F. Castelló-Sirvent   +2 more
doaj   +1 more source

The rs10191329 Risk Allele Is Associated With Pronounced Retinal Layer Atrophy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate whether the rs10191329 risk allele in the DYSF–ZNF638 locus, which is implicated in central nervous system resilience rather than immune‐mediated pathology, is associated with retinal layer thinning, a biomarker of neuroaxonal damage in relapsing multiple sclerosis (RMS). Methods From a prospective observational study,
Gabriel Bsteh, Ruchi Tanavade, Nik Krajnc, Fabian Föttinger, Theresa König, Martin Krenn, Lukas Haider, Barbara Kornek, Fritz Leutmezer, Kerstin U. Ludwig, Stefan Macher, Tobias Monschein, Markus Ponleitner, Paulus Rommer, Christiane Schmied, Karin Zebenholzer, Tobias Zrzavy, Gudrun Zulehner, Franziska Di Pauli, Axel Schmidt, Harald Hegen, Berthold Pemp, Thomas Berger   +22 more
wiley   +1 more source

A natural language processing system for the efficient extraction of cell markers

Scientific Reports
Single-cell RNA sequencing (scRNA-seq) has emerged as a pivotal tool for exploring cellular landscapes across diverse species and tissues. Precise annotation of cell types is essential for understanding these landscapes, relying heavily on empirical ...
Peng Cheng, Yan Peng, Xiao-Ling Zhang, Sheng Chen, Bin-Bin Fang, Yan-Ze Li, Yi-Min Sun   +6 more
doaj   +1 more source