Results 41 to 50 of about 1,353,563 (311)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Do headaches impact pregnancy planning behaviors? A cross-sectional school-based study in Japan

The Journal of Headache and Pain
Objective Headache disorders are a common neurological disease with socioeconomic burdens among individuals of reproductive age, yet little is known about its impact on fertility intentions.
Masahito Katsuki, Yasuhiko Matsumori, Muneto Tatsumoto, Keisuke Suzuki, Daiki Sato, Koki Kikugawa, Shigeharu Kamado, Siobhán O’Connor, Kieran Moran   +8 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Strategic methods for measuring marketing performance of companies in the Republic of Macedonia [PDF]

Strategic Management, 2014
At Google, there is a saying that is frequently used: “Data beats opinion.” In practice, this means that for any activity, we first determine our key success metrics and then measure how we are doing against them on a regular basis.
Todorovska Marinela
doaj  

The impact of marketing oriented product development on new product performance = A marketing orientált termékfejlesztés hatása az új termék teljesítményre [PDF]

, 2009
In the new product innovation management literature a lot of empirical studies have supported the importance of marketing orientation as a key success factor of new products.
Kiss, János
core  

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Holistic concept of marketing performance [PDF]

Marketing i Menedžment Innovacij, 2011
The scope of the article is to provide a critical analysis of ROMI as a metric of marketing performance, and to propose a more comprehensive construct of marketing efficiency, which considers a holistic nature of the concept of modern marketing.
Yu.V. Robul
doaj  

The role of mediation of product innovation in improving enterprises orientation of marketing performance of tofu industry [PDF]

Management Science Letters, 2020
This study aims to analyze the influence of entrepreneurial orientation on marketing performance mediated by product innovation for making tofu and milk in Jombang district.
Hendri Soekotjo, Krido Eko Cahyono, Novianto Eko Nugroho, Rismawati, I Gede Putu Kawiana
doaj   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

Improving Marketing Performance and Product Innovation Capability through Digital Knowledge Sharing: A Case Study in SME`s Food Processing

Journal the Winners, 2023
The research aimed to examine a mediating role of product innovation capability with customer orientation and digital knowledge sharing to increase marketing performance.
Ken Sudarti, Putri Wira Paramita Dewi
doaj   +1 more source