Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang +11 more
wiley +1 more source
The influence of employee mental health on sustainable corporate practices among starred hotels: the roles of marketing performance and stress management. [PDF]
Tutu-Boahene B +3 more
europepmc +1 more source
Trophic Diversity in Duckweed: Mixotrophy, More Than the Sum of its Extremes
In the context of rising DOC in aquatic environments, mixotrophic duckweed may impact carbon cycling by acting as either a carbon sink, as they absorb CO2 through photosynthesis, or a carbon source, as they release CO2 through respiration of absorbed DOC, which depends on DOC concentration, light availability, temperature, and other environmental ...
Zuoliang Sun +5 more
wiley +1 more source
Mapping Research Trends in AI-Based Tourism and Hospitality Marketing: A Bibliometric and Thematic Review. [PDF]
Tyagi PK +4 more
europepmc +1 more source
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang +8 more
wiley +1 more source
The mediating role of relative harm perception in the association between social media marketing exposure-engagement patterns and e-cigarette use behaviors: A cross-sectional study. [PDF]
Kang N, Kang H, Cho SI, Park S.
europepmc +1 more source
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An +11 more
wiley +1 more source
Causal effect estimates of online e-cigarette marketing exposure on future e-cigarette harm perception and use. [PDF]
Harrell PT +7 more
europepmc +1 more source
β‐side chain elimination enables cost‐effective fused‐ring acceptors, JSM5 and JSM6, with simplified synthesis. The observed compact tetrameric structures induced by S···N intermolecular interactions lead to 3D charge transport and enhance intermolecular connectivity, delivering high short‐circuit current density up to 28 mA cm−2, a step closer to the ...
Jinhui Zhao +14 more
wiley +1 more source
AI-driven personalization and impulsive buying in e-commerce: a bibliometric analysis of research trends among Millennials and Generation Z. [PDF]
Monica George A +4 more
europepmc +1 more source

