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Modelling in economic evaluations of medicines [PDF]

open access: yesArhiv za farmaciju, 2021
Economic evaluation in health (also known as pharmacoeconomic in case of medicines) identifies, measures, and values costs and outcomes of alternative healthcare technologies, and can be performed alongside controlled clinical trials, but analytical ...
Lakić Dragana   +3 more
doaj   +1 more source

Markov model- Quantifying outlook towards success of tobacco cessation counseling

open access: yesJournal of Family Medicine and Primary Care, 2022
Smoking is still a major public health issue that causes morbidity and mortality all over the world. The percentage of deaths caused by tobacco smoking has escalated from 1.4% in 1990 to 13.3% by 2020.
Yashasvi Nikose   +6 more
doaj   +1 more source

Assessment of the protection level of continuous production based on the Markov life cycle model [PDF]

open access: yesИзвестия Саратовского университета. Новая серия. Серия Математика. Механика. Информатика, 2022
The article discusses the current level of development of automation technologies for continuous production, taking into account the compliance with the requirements of the fourth industrial revolution Industry 4.0.
Petrov, Dmitry Yurievich
doaj   +1 more source

Finite state machine and Markovian equivalents of the lac Operon in E. coli bacterium

open access: yesAIMS Bioengineering, 2022
The lac operon in E. coli has been extensively studied by computational biologists. The bacterium uses it to survive in the absence of glucose, utilizing lactose for growth.
Urooj Ainuddin, Maria Waqas
doaj   +1 more source

Discrete Time Hybrid Semi-Markov Models in Manpower Planning

open access: yesMathematics, 2021
Discrete time Markov models are used in a wide variety of social sciences. However, these models possess the memoryless property, which makes them less suitable for certain applications.
Brecht Verbeken, Marie-Anne Guerry
doaj   +1 more source

Gene hunting with hidden Markov model knockoffs [PDF]

open access: yesBiometrika, 2017
&NA; Modern scientific studies often require the identification of a subset of explanatory variables. Several statistical methods have been developed to automate this task, and the framework of knockoffs has been proposed as a general solution for ...
Matteo Sesia, C. Sabatti, E. Candès
semanticscholar   +1 more source

Sintilimab Plus Bevacizumab Biosimilar Versus Sorafenib as First-Line Treatment for Unresectable Hepatocellular Carcinoma: A Cost-Effectiveness Analysis

open access: yesFrontiers in Pharmacology, 2022
Objective: The ORIENT-32 clinical trial revealed that sintilimab plus bevacizumab biosimilar significantly improved the median progression-free survival and median overall survival (OS) compared with sorafenib.
Ye Peng   +10 more
doaj   +1 more source

Using Multi-state Markov models to predict the probability of borrowers’ default [PDF]

open access: yesИзвестия Саратовского университета. Новая серия: Серия «Экономика. Управление. Право», 2023
Introduction. After the crises, lenders realized the importance of assessing the risk of default on loan portfolios in various economic conditions. Modeling of credit risk assessment occurs mainly using internal ratings of banks based on probabilistic ...
Balash, Vladimir A.   +2 more
doaj   +1 more source

Concentration of inverted repeats along human DNA

open access: yesJournal of Integrative Bioinformatics, 2023
This work aims to describe the observed enrichment of inverted repeats in the human genome; and to identify and describe, with detailed length profiles, the regions with significant and relevant enriched occurrence of inverted repeats.
Bastos Carlos A. C.   +3 more
doaj   +1 more source

Hierarchical Model Predictive Control for Hydraulic Hybrid Powertrain of a Construction Vehicle

open access: yesApplied Sciences, 2020
Hybrid hydraulic technology has the advantages of high-power density and low price and shows good adaptability in construction machinery. A complex hybrid powertrain architecture requires optimization and management of power demand distribution and an ...
Zhong Wang, Xiaohong Jiao
doaj   +1 more source

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