Results 51 to 60 of about 190,317 (312)
Ancestral graph Markov models [PDF]
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Richardson, Thomas, Spirtes, Peter
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Integrated omics analysis of matched primary and liver metastatic NPC tumors reveals a unique NOTCH1+ CSC subpopulation exhibiting enhanced stemness properties and tumorigenic capacity. With in vitro and in vivo assays, exosomal transfer of tumor‐derived FTO from NOTCH1+ cells to the endothelium promotes vascular permeability and metastatic potential ...
Chun Wu +23 more
wiley +1 more source
Scoring hidden Markov models [PDF]
Statistical sequence comparison techniques, such as hidden Markov models and generalized profiles, calculate the probability that a sequence was generated by a given model. Log-odds scoring is a means of evaluating this probability by comparing it to a null hypothesis, usually a simpler statistical model intended to represent the universe of sequences ...
C, Barrett, R, Hughey, K, Karplus
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Long‐term hippocampal place‐code dynamics are investigated using calcium imaging across weeks of maze navigation. Analyses reveal a novelty‐irrelevant Single‐Field Evolution Rule (SFER), where active fields promote persistence and inactive fields decline.
Cong Chen +10 more
wiley +1 more source
Two Novel S‐methyltransferases Confer Dimethylsulfide Production in Actinomycetota
This study identifies two novel S‐adenosine‐methionine‐dependent methyltransferases, MddM1 and MddM2, in actinomycetes from the Mariana Trench. These enzymes can convert toxic hydrogen sulfide (H2S) and methanethiol (MeSH) into dimethylsulfide (DMS), serving as a cellular detoxification and oxidative stress response.
Ruihong Guo +11 more
wiley +1 more source
Cost Effectiveness of Emollients in the Prevention of Relapses in Atopic Dermatitis
Elise Cabout,1 Sebastien Eymere,1 Robert Launois,1 Flavia Aslanian,2 Charles Taïeb,3,4 Sophie Seité5 1Réseau d’évaluation en Économie de la Santé (REES), Paris, France; 2Epsom and St Helier University ...
Cabout E +5 more
doaj
Graphical Markov Models: Overview [PDF]
We describe how graphical Markov models started to emerge in the last 40 years, based on three essential concepts that had been developed independently more than a century ago. Sequences of joint or single regressions and their regression graphs are singled out as being best suited for analyzing longitudinal data and for tracing developmental pathways.
Wermuth, Nanny, Cox, D. R.
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Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming
Single‐cell profiling of TF‐induced forward programming versus stepwise dual‐SMAD differentiation reveals that divergent trajectories set the pace of neurogenesis. OLIG TFs advance cell‐cycle exit via NOTCH modulation, while NEUROD2 later accelerates maturation. The study elucidates transcriptional mechanisms governing differentiation timing, providing
Lingling Zhu +13 more
wiley +1 more source
Summary Markov Models for Event Sequences [PDF]
Debarun Bhattacharjya +3 more
openalex +1 more source
This study presents a novel microscopic imaging system capable of rapid, section‐free scanning of irregular tissue surfaces, delivering high sensitivity for detecting cancer cell clusters during intraoperative tumor margin assessment. Abstract Rapid and accurate intraoperative examination of tumor margins is crucial for precise surgical treatment, yet ...
Zhicheng Shao +17 more
wiley +1 more source

