Results 141 to 150 of about 151,951 (312)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Large drainage systems produced half of Mars' ancient river sediment. [PDF]

Proc Natl Acad Sci U S A
Zaki AS, Goudge TA, Mohrig D.
europepmc   +1 more source

Mar

, 2014
Hay un mar más allá del mar Sin peces sin vientos Un mar sin sol,sin sal, sin barcas Su inmenso fondo metálico No refleja lunas ni estrellas ni dioses Un mar que se extiende inabarcable Como el lomo gris de una ballena Ardiendo en el desierto.
openaire   +1 more source

Colloque sur les Recherches Fruitières INRA-CTIFL, Bordeaux, 16-17 mars 1983

, 1983
Xavier Perrier
openalex   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Emerging Chemical and Biological Materials Technologies in the Extraplanetary Environment. [PDF]

Nanomicro Lett
Jiang Q, Wang B, Cheng Y, Wang Y, Zhao H, Lu Y.   +5 more
europepmc   +1 more source

Evaluating the Use of Seasonal Surface Displacements and Time‐Variable Gravity to Constrain the Interior of Mars [PDF]

Nick Wagner, P. B. James, A. Ermakov, Michael M. Sori   +3 more
openalex   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

The role of extremophile microbiomes in terraforming Mars. [PDF]

Commun Biol
Coleine C, Delgado-Baquerizo M, Rosado AS, Zerboni A.   +3 more
europepmc   +1 more source