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RETRACTION: lncRNA‐PDPK2P Promotes Hepatocellular Carcinoma Progression Through the PDK1/AKT/Caspase 3 Pathway

Molecular Oncology, EarlyView.
RETRACTION: W. Pan, W. Li, J. Zhao, Z. Huang, J. Zhao, S. Chen, C. Wang, Y. Xue, F. Huang, Q. Fang, J. Wang, D. Brand, and S. G. Zheng, “lncRNA‐PDPK2P Promotes Hepatocellular Carcinoma Progression Through the PDK1/AKT/Caspase 3 Pathway,” Molecular Oncology 13, no. 10 (2019): 2246–2258, https://doi.org/10.1002/1878-0261.12553.
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Mas receptor endocytosis and signaling in health and disease

2023
The renin angiotensin system (RAS) plays a major role in blood pressure regulation and electrolyte homeostasis and is mainly composed by two axes mediating opposite effects. The pressor axis, constituted by angiotensin (Ang) II and the Ang II type 1 receptor (AT1R), exerts vasoconstrictor, proliferative, hypertensive, oxidative and pro-inflammatory ...
Natalia L, Rukavina Mikusic, Mariela M, Gironacci   +1 more
openaire   +2 more sources

The mas oncogene encodes an angiotensin receptor

Nature, 1988
The class of receptors coupled to GTP-binding proteins share a conserved structural motif which is described as a 'seven-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. Identified examples include the mammalian opsins, alpha 1-, alpha 2-, beta 1- and beta 2-adrenergic receptors, the ...
Michel Goedert, J. Marshall, T. R. Jackson, L. A. C. Blair, L. A. C. Blair, Michael R. Hanley   +5 more
openaire   +3 more sources

Angiotensin type 2 receptor (AT2R) and receptor Mas: a complex liaison

Clinical Science, 2014
The angiotensin type 2 receptor (AT2R) and the receptor Mas are components of the protective arms of the renin–angiotensin system (RAS), i.e. they both mediate tissue protective and regenerative actions. The spectrum of actions of these two receptors and their signalling mechanisms display striking similarities. Moreover, in some instances, antagonists
Anders Hallberg, Sebastian Kirsch, Thomas Unger, Colin Sumners, Neal A. Patel, Daniel C. Villela, Daniel C. Villela, Jason P. Joseph, Michael Bader, U. Muscha Steckelings, U. Muscha Steckelings, Robson A.S. Santos, Julia Leonhardt   +12 more
openaire   +5 more sources

Mas Receptor Agonists as Novel Antihypertensive Agents

Current Hypertension Reviews, 2012
It is well known that the renin-angiotensin system (RAS) plays a pivotal role in the control of the cardiovascular and renal systems and in the pathogenesis of cardiovascular and renal diseases. The classical concept of the RAS has been changed in the recent years by the inclusion of novels components. Among the novel components of the RAS, Angiotensin(
Robson A.S. Santos, Rodrigo A. Fraga-Silva, Anderson J. Ferreira, Silvia Q Savergnini   +3 more
openaire   +2 more sources

Expression of the Mas receptor is upregulated in skeletal muscle wasting

Histochemistry and Cell Biology, 2014
Skeletal muscle atrophy during sepsis, immobilization, and chronic diseases is characterized by an increase in expression and activity of the muscle-specific ubiquitin 3 ligases atrogin-1 and MuRF-1. The classical renin-angiotensin system (RAS), by high level of circulating angiotensin II (AngII) is directly involved in skeletal muscle wasting ...
Felipe Simon, Felipe Simon, Carla Meneses, María Gabriela Morales, Johanna Abrigo, Franco Cisternas, Claudio Cabello-Verrugio   +6 more
openaire   +3 more sources

Mas receptor contributes to pregnancy-induced cardiac remodelling

Clinical Science, 2016
Previous studies have demonstrated a protective effect of the Ang-(1–7)/Mas receptor axis on pathological cardiac hypertrophy. Also, the involvement of Mas receptor in exercise-induced cardiac hypertrophy has been suggested. However, the role of the Ang-(1–7)/Mas receptor on pregnancy-induced cardiac remodelling remains unknown.
Marcos B. Melo, Larissa Matuda Macedo, Fernanda C. A. Santos, Carlos H. Castro, Carlos H. Castro, Manoel F. Biancardi, Robson A.S. Santos, Robson A.S. Santos, Adryano Augustto Valladão de Carvalho, Jônathas Fernandes Queiroz de Almeida, Diego Basile Colugnati, Gustavo Rodrigues Pedrino, Cintia do Carmo e Silva, Renata Mazaro-Costa, Elizabeth Pereira Mendes   +14 more
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Participation of AT1 and Mas receptors in the modulation of inflammatory pain

Peptides, 2014
We investigated the mechanisms underlying the endogenous control of nociception at the peripheral level during inflammation. We hypothesized that angiotensin receptors could modulate pain at the peripheral level via endogenous processes because angiotensin receptors are present in peripheral nerve terminals.
Igor D.G. Duarte, Aline C.O. Costa, Andrea C. Perez, Daniela da Fonseca Pacheco, Robson R.A. Santos, Atila Savernini, Thiago Roberto Lima Romero   +6 more
openaire   +3 more sources

Interaction Between Mas and the Angiotensin AT1 Receptor in the Amygdala

Journal of Neurophysiology, 2000
The Mas-protooncogene is a maternally imprinted gene encoding an orphan G protein–coupled receptor expressed mainly in limbic structures of the rodent CNS. Because Mas and the product of the Mas-related gene enhance the effects of angiotensins on cells expressing angiotensin receptors of the AT1 subtype, we first compared the distribution of cells ...
Doris Albrecht, Oliver von Bohlen und Halbach, Thomas Walther, Michael Bader   +3 more
openaire   +3 more sources

Characterization and regulation of prolactin receptors in MA-10 Leydig cells

Molecular and Cellular Endocrinology, 1998
The aim of this study is to further characterize the prolactin receptors (PRL-R) previously reported in the murine Leydig tumor MA-10 cell line, as well as to study their homologous and heterologous regulation. Two forms of PRL-R, a high and a low molecular weight form, were revealed by studies of covalent crosslinking of 125I-human GH to cultured MA ...
Tamar Amit, Rosalie Ber, Esther Weiss-Messer, R. J. Barkey   +3 more
openaire   +3 more sources