Results 321 to 330 of about 342,617 (351)
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20-Hydroxyecdysone activates the protective arm of the RAAS via the MAS receptor
Journal of Molecular Endocrinology, 202220-Hydroxyecdysone (20E) is a steroid hormone that plays a key role in insect development through nuclear ecdysteroid receptors (EcR/RXR complex) and at least one membrane GPCR receptor (DopEcR). It also displays numerous pharmacological effects in mammals, where its mechanism of action is still debated, involving either an unidentified GPCR or the ...
René Lafont +9 more
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Pharmacology and Signaling of MAS-Related G Protein–Coupled Receptors
Pharmacological Reviews, 2014Signaling by heptahelical G protein-coupled receptors (GPCR) regulates many vital body functions. Consequently, dysfunction of GPCR signaling leads to pathologic states, and approximately 30% of all modern clinical drugs target GPCR. One decade ago, an entire new GPCR family was discovered, which was recently named MAS-related G protein-coupled ...
Andreas Breit +2 more
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Mas receptors in modulating relaxation induced by perivascular adipose tissue
Life Sciences, 2011Perivascular adipose tissue (PVAT) is known to secrete vascular relaxation factors, and angiotensin 1-7 [Ang-(1-7)] acting on the endothelium is one of the endothelium-dependent relaxation factors. Mas protein is the receptor for Ang-(1-7). Using aorta from Mas-knockout (K/O) and wild type (FVB) mice, we wished to establish the essential role of Mas ...
Natalia Alenina +5 more
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The role of Mas receptors in an experimental rat glaucoma model
Acta Ophthalmologica, 2011AbstractPurpose To evaluate the neuroprotective and/or oculohypotensive effects of potent angiotensin system agents known to reduce intraocular pressure in the normotensive rabbits by using an experimental laser‐induced glaucoma model in rat eye.Methods Experimental glaucoma was induced unilaterally using laser photocoagulation of the episcleral and ...
Heikki Vapaatalo +3 more
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Mas and Its Related G Protein–Coupled Receptors, Mrgprs
Pharmacological Reviews, 2014The Mas-related G protein-coupled receptors (Mrgprs or Mas-related genes) comprise a subfamily of receptors named after the first discovered member, Mas. For most Mrgprs, pruriception seems to be the major function based on the following observations: 1) they are relatively promiscuous in their ligand specificity with best affinities for itch-inducing ...
Michael Bader +3 more
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Stabilization of the angiotensin-(1–7) receptor Mas through interaction with PSD95
Biochemical Journal, 2013The functions and signalling mechanisms of the Ang-(1–7) [angiotensin-(1–7)] receptor Mas have been studied extensively. However, less attention has been paid to the intracellular regulation of Mas protein. In the present study, PSD95 (postsynaptic density 95), a novel binding protein of Mas receptor, was identified, and their association was ...
Jia Hu +15 more
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Angiotensin metabolites can stimulate receptors of the Mas-related genes family
Molecular and Cellular Biochemistry, 2008The Mas protooncogene encodes a G protein-coupled receptor, we identified, also by using the specific angiotensin-(1-7) antagonist A-779, to be associated with intracellular signaling of the angiotensin (Ang) II metabolite Ang-(1-7). Recently, Mas-related genes (Mrg) have been identified coding for the Mrg-receptor family. All family members share high
Martin Vahl +5 more
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Immunofluorescence localization of the receptor Mas in cardiovascular-related areas of the rat brain
American Journal of Physiology-Heart and Circulatory Physiology, 2007The G protein-coupled receptor Mas was recently described as an angiotensin-(1–7) [ANG-(1–7)] receptor. In the present study we evaluated the anatomical localization of Mas using immunofluorescence in the central nervous system of adult male Wistar rats. An abundant labeling was found in the hippocampus, amigdala, anterodorsal thalamic nucleus, cortex,
Robson A.S. Santos +4 more
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Immunohistochemical localization of the angiotensin-(1–7) receptor Mas in the murine forebrain
Cell and Tissue Research, 2012Apart from the well-known biologically active angiotensin II, other biologically active angiotensins have been discovered, including angiotensin IV and angiotensin-(1-7). Some years ago, we and others discovered that the Mas proto-oncogene encodes a receptor that is essential for angiotensin-(1-7) signaling.
Thomas Walther +2 more
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Mas receptor blockade impairs exercise-induced cardiac hypertrophy
PeptidesExercise training leads to physiological cardiac hypertrophy and the protective axis of the renin-angiotensin system composed of angiotensin-converting enzyme 2, angiotensin-(1-7), and Mas receptor seems involved in this process. However, the role of the basal activity of the Mas receptor in exercise-induced physiological cardiac hypertrophy is still ...
Christoffer Novais de Farias, Silva +12 more
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