Results 41 to 50 of about 643,213 (261)

How improvements to drug effectiveness impact mass drug administration for control and elimination of schistosomiasis [PDF]

PLoS Neglected Tropical Diseases
John R. Ellis, Nyamai Mutono, Andreia Vasconcelos, Samuel M. Thumbi, T. Déirdre Hollingsworth, Roy M. Anderson   +5 more
doaj   +1 more source

An observational assessment of the safety of mass drug administration for trachoma in Ethiopian children [PDF]

, 2022
Allan Ciciriello, David G. Addiss, Tesfaye Teferi, Paul M. Emerson, Pamela J. Hooper, Mohammed Seid, Girma Tadesse, Fikre Seife, Mohammed-Aman Jemal Sormolo, Fikreab Kebede, Genet Kiflu, Sheila K. West, Menbere Alemu, Genevieve LaCon, Teshome Gebre   +14 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Mass drug administration can be a valuable addition to the malaria elimination toolbox

Malaria Journal, 2019
The Global Technical Strategy 2016–2030 of the World Health Organization (WHO) has the ambitious goal of malaria being eliminated from at least 35 countries by 2030.
Thomas P. Eisele
doaj   +1 more source

Pharmacokinetics, feasibility and safety of co-administering azithromycin, albendazole, and ivermectin during mass drug administration: A review.

PLoS Neglected Tropical Diseases, 2023
IntroductionTraditionally, health ministries implement mass drug administration programmes for each neglected tropical disease (NTD) as separate and distinct campaigns.
Scott McPherson, Anthony W Solomon, Fikre Seife, Hiwot Solomon, Teshome Gebre, David C W Mabey, Michael Marks   +6 more
doaj   +1 more source

PA-767 Prevalence and risk factors of urinary schistosomiasis in northern Malawi – An assessment of mass drug administration and community perceptions of the disease [PDF]

, 2023
Rosheen Mthawanji, Christopher S. Nyondo, Master Chisale, Kestern Mkoola   +3 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Zoonotic Schistosomiasis: The Crossroads Between Animal and Human Schistosomiasis in Africa: Narrative Review

Health Science Reports
Background The fight against schistosomiasis (urogenital and intestinal) has prolonged more than expected with more areas that were previously known to have less or no incidence of infection now recording alarming incidence rate.
Fatima Amponsah Fordjour, Alexander Kwarteng   +1 more
doaj   +1 more source

Biannual versus annual mass azithromycin distribution and malaria seroepidemiology among preschool children in Niger: a sub-study of a cluster randomized trial

Malaria Journal, 2019
Background Biannual mass azithromycin administration to preschool children reduces all-cause mortality, but the mechanism for the effect is not understood.
Catherine E. Oldenburg, Abdou Amza, Gretchen Cooley, Boubacar Kadri, Beido Nassirou, Benjamin F. Arnold, Philip J. Rosenthal, Kieran S. O’Brien, Sheila K. West, Robin L. Bailey, Travis C. Porco, Jeremy D. Keenan, Thomas M. Lietman, Diana L. Martin   +13 more
doaj   +1 more source

Mass drug administration for trachoma: how long is not long enough? [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:Blinding trachoma is targeted for elimination by 2020 using the SAFE strategy (Surgery, Antibiotics, Facial cleanliness, and Environmental improvements). Annual mass drug administration (MDA) with azithromycin is a cornerstone of this strategy.
Violeta Jimenez, Huub C Gelderblom, Rebecca Mann Flueckiger, Paul M Emerson, Danny Haddad   +4 more
doaj   +1 more source