Results 51 to 60 of about 7,151,878 (288)

Prevalence of Wuchereria Bancrofti Antigenemia and Associated Factors Among Children of School Age Born After Initiation of Mass Drug Administration with ivermectin and albendazole in Rufiji district, Tanzania [PDF]

, 2012
The National Lymphatic Filariasis (LF) Elimination Programme use Ivermectin and Albendazole mass drug administration (MDA) for the control of LF. Screening children of school age has successfully been used for mapping geographical distribution of LF ...
Clarer, J., Clarer, Jones
core  

The cost of antibiotic mass drug administration for trachoma control in a remote area of South Sudan. [PDF]

, 2011
BACKGROUND: Mass drug administration (MDA) of antibiotics is a key component of the so-called "SAFE" strategy for trachoma control, while MDA of anthelminthics provides the cornerstone for control of a number of other neglected tropical diseases (NTDs ...
Jan H Kolaczinski, Emily Robinson, Timothy P. Finn, Kolaczinski, Jan H, Robinson, Emily, Timothy P Finn, Kolaczinski Jan H., Robinson Emily, Jan H. Kolaczinski, Finn, Timothy P, Finn Timothy P.   +10 more
core   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

How well do coverage surveys and programmatically reported mass drug administration coverage match? Results from 214 mass drug administration campaigns in 15 countries, 2008–2017

BMJ Global Health, 2023
Introduction Delivering preventive chemotherapy through mass drug administration (MDA) is a central approach in controlling or eliminating several neglected tropical diseases (NTDs).
Karsor Kollie, Nebiyu Negussu, Scott D Nash, Donal Bisanzio, Fiona M Fleming, Pamela S Mbabazi, Richard Reithinger, Kathryn L Zoerhoff, Katherine Gass, John Kraemer, Brian B Fuller, Lynsey Blair, Roland Bougma, Aboulaye Meite, Bizuayehu Gashaw, Nana-Kwadwo Biritwum, Jean Frantz Lemoine, Helena Ullyartha Pangaribuan, Eksi Wijayanti, Clara Fabienne Rasoamanamihaja, Lazarus Juziwelo, Square Mkwanda, Pradip Rimal, Issa Gnandou, Bocar Diop, Ameyo Monique Dorkenoo, Rachel Bronzan, Edridah Muheki Tukahebwa, Fatima Kabole, Violetta Yevstigneyeva, Lauren Courtney, Joseph Koroma, Egide Endayishimye, Margaret C Baker   +33 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The potential contribution of mass treatment to the control of plasmodium falciparum malaria [PDF]

, 2011
Mass treatment as a means to reducing P. falciparum malaria transmission was used during the first global malaria eradication campaign and is increasingly being considered for current control programmes.
Bousema, Teun, Ghani, Azra C, Chris J. Drakeley, Lucy C. Okell, White, Michael J., Michael J White, Azra C Ghani, White Michael J., Ghani, AC, Hollingsworth T. Déirdre, Kleinschmidt Immo, Griffin, JT, Okell Lucy C., Jamie T. Griffin, Ghani, Azra C., Griffin, Jamie T, Bousema Teun, Jamie T Griffin, Churcher Thomas S., T. Déirdre Hollingsworth, Ghani Azra C., Chris J Drakeley, Drakeley, Chris J, White, Michael J, Griffin, Jamie T., Lucy C Okell, Kleinschmidt, Immo, Drakeley, CJ, Hollingsworth, TD, Hollingsworth, T. Déirdre, Okell, Lucy C, Churcher, Thomas S, Griffin Jamie T., Teun Bousema, Azra C. Ghani, Thomas S Churcher, White, MJ, T Déirdre Hollingsworth, Thomas S. Churcher, Bousema, T, Churcher, TS, Drakeley, Chris J., Immo Kleinschmidt, Churcher, Thomas S., Drakeley Chris J., Okell, LC, Okell, Lucy C., Michael J. White, Hollingsworth, T Déirdre, Kleinschmidt, I   +49 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

The processes of reform in Victoria’s alcohol and other drug sector, 2011-2014 [PDF]

, 2014
This paper explores issues and concerns related to the 2014 alcohol and other drug sector recommissioning process in Victoria. Overview In mid-2014, the Victorian Alcohol and Drug Association approached the Drug Policy Modelling Program, at the ...
Drug Policy Modelling Program
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

New approaches to measuring anthelminthic drug efficacy : parasitological responses of childhood schistosome infections to treatment with praziquantel [PDF]

, 2015
By 2020, the global health community aims to control and eliminate human helminthiases, including schistosomiasis in selected African countries, principally by preventive chemotherapy (PCT) through mass drug administration (MDA) of anthelminthics ...
Scherrer, A U, Raso, G, Utzinger, Jürg, Alexandra U. Scherrer, King, Charles H., Coulibaly, Jean T., Walker, Martin, Basanez, MG, Jean T. Coulibaly, Basáñez, M-G, King, CH, Martin Walker, Walker, M, Scherrer, Alexandra U., Sousa-Figueiredo, José Carlos, Katarina Stete, Mabud, Tarub S., Mabud, T, Stete, Katarina, Basáñez, Maria-Gloria, Coulibaly, J T, José Carlos Sousa-Figueiredo, Jürg Utzinger, Maria-Gloria Basáñez, Utzinger, J, Giovanna Raso, Scherrer, AU, Raso, Giovanna, Olliaro, Piero L., Stothard, JR, Stothard, J R, Sousa-Figueiredo, J C, Olliaro, PL, Coulibaly, JT, Sousa-Figueiredo, JC, Stothard, J. Russell, Charles H. King, King, C H, J. Russell Stothard, Tarub S. Mabud, Piero L. Olliaro, Olliaro, P L, Stete, K   +42 more
core   +1 more source