Results 41 to 50 of about 687,738 (249)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Comparison of coverage and compliance of mass drug administration 2017 in urban & rural areas of Valsad district, Gujarat, India

Journal of Integrated Health Sciences, 2017
Context: Filariasis, an infectious tropical disease is a major public health problem in India but remains neglected. This study was conducted with an objective to evaluate and compare the coverage and compliance of Mass Drug Administration (MDA) and ...
Anupam Verma, Rachna Prasad, N B Patel, R K Bansal   +3 more
doaj   +1 more source

The impact of mass drug administration of antibiotics on the gut microbiota of target populations

Infectious Diseases of Poverty, 2022
Antibiotics have become a mainstay of healthcare in the past century due to their activity against pathogens. This manuscript reviews the impact of antibiotic use on the intestinal microbiota in the context of mass drug administration (MDA).
Ethan K. Gough
doaj   +1 more source

Effectiveness of azithromycin mass drug administration on trachoma: a systematic review

Chinese Medical Journal, 2021
Backgrounds:. Azithromycin mass drug administration (MDA) is a key part of the strategy for controlling trachoma. This systematic review aimed to comprehensively summarize the present studies of azithromycin MDA on trachoma; provide an overview of the ...
Tao Xiong, Yan Yue, Wen-Xing Li, Imti Choonara, Shamim Qazi, Hong-Ju Chen, Jun Tang, Jing Shi, Hua Wang, Li-Nan Zeng, Bin Xia, Li-Na Qiao, Yi Qu, De-Zhi Mu, Jing Ni   +14 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Zoonotic Schistosomiasis: The Crossroads Between Animal and Human Schistosomiasis in Africa: Narrative Review

Health Science Reports
Background The fight against schistosomiasis (urogenital and intestinal) has prolonged more than expected with more areas that were previously known to have less or no incidence of infection now recording alarming incidence rate.
Fatima Amponsah Fordjour, Alexander Kwarteng   +1 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Factors Associated With Coverage in Community-directed Treatment With Ivermectin for Onchocerciasis Control in Savanah and Forest Areas in Central African Republic: A Cross-sectional Study [PDF]

Journal of Preventive Medicine and Public Health
Objectives: The aim of this study was to identify factors associated with coverage in community-directed treatment with ivermectin for onchocerciasis control in savannah and forest areas in the Central African Republic.
Sylvain Honoré Woromogo, Stéphanie Inesse Garoua-Adjou, Ange Donatien Ngouyombo, Rodrigue Herman Doyama-Woza, Henri Saint Calvaire Diemer, Jean de Dieu Longo   +5 more
doaj   +1 more source

Rapid progress towards elimination of lymphatic filariasis in endemic regions of Myanmar as a result of 16 years of anti-filarial activities (2001–2016)

Tropical Medicine and Health, 2018
Background As Myanmar progresses towards lymphatic filariasis (LF) elimination, it is important to know how well the anti-filarial activities have performed.
Kyawt Mon Win, Jaya Prasad Tripathy, Thae Maung Maung, Tin Oo, Aung Thi, Khin Nan Lon, Zaw Lin   +6 more
doaj   +1 more source