Results 71 to 80 of about 983,966 (332)

Biannual versus annual mass azithromycin distribution and malaria seroepidemiology among preschool children in Niger: a sub-study of a cluster randomized trial

Malaria Journal, 2019
Background Biannual mass azithromycin administration to preschool children reduces all-cause mortality, but the mechanism for the effect is not understood.
Catherine E. Oldenburg, Abdou Amza, Gretchen Cooley, Boubacar Kadri, Beido Nassirou, Benjamin F. Arnold, Philip J. Rosenthal, Kieran S. O’Brien, Sheila K. West, Robin L. Bailey, Travis C. Porco, Jeremy D. Keenan, Thomas M. Lietman, Diana L. Martin   +13 more
doaj   +1 more source

Neurocysticercosis: Current Perspectives on Diagnosis and Management

Frontiers in Veterinary Science, 2021
Porcine cysticercosis, human taeniasis, and (neuro)cysticercosis are endemic in many low- and middle-income countries (LMIC) where they present a significant health burden to affected communities.
Caitlin Butala, Caitlin Butala, T. M. Brook, Ayodele O. Majekodunmi, Ayodele O. Majekodunmi, Susan Christina Welburn, Susan Christina Welburn   +6 more
doaj   +1 more source

Differential expression of skeletal muscle genes following administration of clenbuterol to exercised horses. [PDF]

, 2016
BackgroundClenbuterol, a beta2-adrenergic receptor agonist, is used therapeutically to treat respiratory conditions in the horse. However, by virtue of its mechanism of action it has been suggested that clenbuterol may also have repartitioning affects in
Chouicha, Nadira, Harrison, Linda M, Kass, Phil H, Knych, Heather K, Steinmetz, Stacy J   +4 more
core   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Pharmacokinetics, feasibility and safety of co-administering azithromycin, albendazole, and ivermectin during mass drug administration: A review.

PLoS Neglected Tropical Diseases, 2023
IntroductionTraditionally, health ministries implement mass drug administration programmes for each neglected tropical disease (NTD) as separate and distinct campaigns.
Scott McPherson, Anthony W Solomon, Fikre Seife, Hiwot Solomon, Teshome Gebre, David C W Mabey, Michael Marks   +6 more
doaj   +1 more source

Effectiveness of a triple-drug regimen for global elimination of lymphatic filariasis: a modelling study [PDF]

, 2016
Background: Lymphatic filariasis is targeted for elimination as a public health problem by 2020. The principal approach used by current programmes is annual mass drug administration with two pairs of drugs with a good safety profile. However, one dose of
Hollingsworth, TD, Irvine, MA, Michael, E, Singh, BK, Smith, ME, Stolk, Wilma, Subramanian, S, Weil, GJ   +7 more
core   +6 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

A stochastic model for the probability of malaria extinction by mass drug administration [PDF]

Malaria Journal, 2017
Mass drug administration (MDA) has been proposed as an intervention to achieve local extinction of malaria. Although its effect on the reproduction number is short lived, extinction may subsequently occur in a small population due to stochastic fluctuations.
Peter Pemberton-Ross, Peter Pemberton-Ross, Nakul Chitnis, Nakul Chitnis, Emilie Pothin, Emilie Pothin, Thomas J. Smith, Thomas J. Smith   +7 more
openaire   +5 more sources

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Mass drug administration should be implemented as a tool to accelerate elimination: against

Malaria Journal, 2019
In most malaria situations, mass drug administration (MDA) will result in a rapid reduction in the incidence and prevalence of malaria in the target population.
Kamini Mendis
doaj   +1 more source