Results 71 to 80 of about 643,213 (261)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Coverage evaluation surveys following soil-transmitted helminthiasis and schistosomiasis mass drug administration in Wolaita Zone of Ethiopia—The Geshiyaro project

, 2021
Ewnetu Firdawek Liyew, Melkie Chernet, Habtamu Gebrehana Belay, Rosie Maddren, Toby Landeryou, Suprabhath Kalahasti, Alison Ower, Kalkidan Mekete, Anna E. Phillips, Ufaysa Anjulo, Tujuba Endrias, Adugna Tamiru, Bokretsion Gidey, Zelalem Mehari, Birhan Mengistu, Getachew Tollera, Geremew Tasew   +16 more
openalex   +2 more sources

Multiomics integration of 16S rRNA, metagenomic, and metabolomic analyses unveils gut microbiota–metabolite interactions in Guizhi Fuling capsule‐treated chronic pelvic inflammatory disease rats

Advanced Chinese Medicine, EarlyView.
Guizhi Fuling capsule likely alleviates chronic pelvic inflammatory disease by exerting anti‐inflammatory effects, restoring TCA cycle energy metabolism, reshaping gut microbiota structure, inhibiting quorum sensing signaling, and improving polysaccharide metabolic functions.
Hongli Chen, Mengyu Qian, Zhelong Feng, Xia Gao, Ruotong Huang, Yan Xie, Liang Cao, Xialin Chen, Wei Xiao   +8 more
wiley   +1 more source

The feasibility and acceptability of mass drug administration for malaria in Cambodia: a mixed-methods study [PDF]

, 2018
Thomas J. Peto, Rupam Tripura, Nou Sanann, Bipin Adhikari, James J. Callery, Mark Droogleever, Chhouen Heng, Phaik Yeong Cheah, Chan Davoeung, Chea Nguon, Lorenz von Seidlein, Arjen M. Dondorp, Christopher Pell   +12 more
openalex   +1 more source

The dangers of mass drug administration of albendazole in Nepal, a Neurocysticercosis-endemic region [PDF]

, 2020
Gaurav Nepal, Ghanshyam Kharel, Yow Ka Shing, Rajeev Ojha, Sujan Jamarkattel, Jayant Kumar Yadav, Himani Vyas, Dhiraj Poudyal, Ranjit Sah   +8 more
openalex   +1 more source

Characteristics of Cerebral Palsy in the Midwestern US

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebral palsy (CP) is the most common lifelong motor disability worldwide. Yet, data is limited on how CP manifests in the US. Our objective was to characterize and determine factors affecting functional outcomes in a large population of young people with CP in the Midwestern US.
Susie Kim, Kelsey Steffen, Lauren Gottschalk‐Henneberry, Jennifer Miros, Amy Robichaux‐Viehoever, Karen Taca, Bhooma R. Aravamuthan   +6 more
wiley   +1 more source

A Study of Coverage and Compliance of Mass Drug Administration for Elimination of Lymphatic Filariasis in Rewa District Of Madhya Pradesh

National Journal of Community Medicine, 2014
Introduction: Lymphatic filariasis (LF), commonly known as elephantiasis is a global problem affecting more than 120 million people in 80 countries. It is one of the leading causes of long term permanent disability, accounting for more than 5 million ...
Amarnath Gupta, Pankaj Prasad, Sukhendra P Singh   +2 more
doaj  

Diffusion Tractography Biomarker for Epilepsy Severity in Children With Drug‐Resistant Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To develop a novel deep‐learning model of clinical DWI tractography that can accurately predict the general assessment of epilepsy severity (GASE) in pediatric drug‐resistant epilepsy (DRE) and test if it can screen diverse neurocognitive impairments identified through neuropsychological assessments.
Jeong‐Won Jeong, Min‐Hee Lee, Hiroshi Uda, Yoon Ho Hwang, Michael Behen, Aimee Luat, Csaba Juhász, Eishi Asano   +7 more
wiley   +1 more source