Results 81 to 90 of about 983,966 (332)

Hybridisations within the genus Schistosoma: implications for evolution, epidemiology and control [PDF]

, 2016
SUMMARYHybridization of parasites is an emerging public health concern in our changing world. Hybridization and introgression in parasites and pathogens can have major impacts on the host and the epidemiology and evolution of disease.
Leger, E, Webster, J P
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Measuring and modelling the effects of systematic non-adherence to mass drug administration [PDF]

Epidemics, 2017
It is well understood that the success or failure of a mass drug administration campaign critically depends on the level of coverage achieved. To that end coverage levels are often closely scrutinised during campaigns and the response to underperforming campaigns is to attempt to improve coverage. Modelling work has indicated, however, that the quality
Louise Dyson, Wilma A. Stolk, Sam H. Farrell, T. Déirdre Hollingsworth   +3 more
openalex   +8 more sources

Opportunities to investigate the effects of ivermectin mass drug administration on scabies [PDF]

Parasites & Vectors, 2013
Abstract The recent article by Mohammed et al. demonstrates an impressive effect of ivermectin mass drug administration for lymphatic filariasis on the burden of scabies. Partnering scabies research within the evaluation and monitoring of Neglected Tropical Disease programmes could potentially increase our understanding of the epidemiology ...
Engelman, D, Martin, DL, Hay, RJ, Chosidow, O, McCarthy, JS, Fuller, LC, Steer, AC   +6 more
openaire   +4 more sources

Anthropometric indices of Gambian children after one or three annual rounds of mass drug administration with azithromycin for trachoma control. [PDF]

, 2014
BACKGROUND: Mass drug administration (MDA) with azithromycin, carried out for the control of blinding trachoma, has been linked to reduced mortality in children.
A Amza, A Amza, A Sommer, A Weisz, AE Roth, AJ Weisz, Ansumana Sillah, C Nokes, C Panter-Brick, CG Victora, CJ Whitty, CL Coles, CL Coles, D Stare, David C W Mabey, EJ Giamarellos-Bourboulis, EK Gough, EM Harding-Esch, EM Harding-Esch, Emma M Harding-Esch, EV Basilion, I Udan, JD Keenan, JH Humphrey, John Hart, KL Kotloff, KN Ryan, L Leonor Rodríguez, LS Stephenson, Martin J Holland, MG Rowland, MG Rowland, MP Eccles, P Aaby, PG Lunn, R Goto, RL Guerrant, Robin L Bailey, S Haug, Sarah E Burr, T Edwards, Tansy Edwards, TC Porco, WHO, WHO, WHO, WHO   +46 more
core   +2 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Mass drug administration for malaria burden reduction

, 2022
Report considered by the WHO/GMP Guideline Development Group on Malaria Chemoprevention for “Section 4.2.6.1 MDA for burden reduction” of the WHO Guidelines for malaria, 3 June 2022.
Schneider Z, Shah M, Boily M, Busbee A, Hwang J, Gutman J   +5 more
openaire   +2 more sources

Response to malaria epidemics in Africa. [PDF]

, 2007
Malaria epidemics affect nonimmune populations in many highland and semi-arid areas of Africa. Effective prevention of these epidemics is challenging, particularly in the highlands where predictive accuracy of indicators is not sufficiently high to allow
Abeku, Tarekegn A
core   +3 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Total Mass TCI driven by Parametric Estimation [PDF]

, 2009
This paper presents the Total Mass Target Controlled Infusion algorithm. The system comprises an On Line tuned Algorithm for Recovery Detection (OLARD) after an initial bolus administration and a Bayesian identification method for parametric estimation ...
Claudia Sousa, Joao Gama, Margarida M Silva, Paula Rocha, Raquel Sebastiao, Simao Esteves, Teresa Mendonca   +6 more
core   +1 more source