Results 81 to 90 of about 3,177,228 (297)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Critical Criterion for Flame Spread Acceleration of Concave Surfaces with Different Curvatures

Fire
Concave surface is a common geometry in both industrial buildings and natural environments; the flame spread behaviors on this special surface are worth studying, while few studies have been completed yet.
Yang Zhou, Haoteng Chen, Xu Yan
doaj   +1 more source

Degradation Rates of Pure Zinc, Magnesium, and Magnesium Alloys Measured by Volume Loss, Mass Loss, and Hydrogen Evolution

Applied Sciences, 2018
Degradation rate is an important property to evaluate bioabsorbable metallic material; however, values vary depending on the method of measurement. In this study, three different methods of measuring corrosion rate are compared. The degradable samples to
Lumei Liu, Kassu Gebresellasie, Boyce Collins, Honglin Zhang, Zhigang Xu, Jagannathan Sankar, Young-Choon Lee, Yeoheung Yun   +7 more
doaj   +1 more source

Red Supergiant Mass Loss and Mass-Loss Rates

Galaxies
This review discusses the causes, nature, importance and observational evidence of mass loss by red supergiants. It arrives at the perception that mass loss finds its origin in the gravity which makes the star a star in the first place, and is a mechanism for the star to equilibrate.
openaire   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Formulating Mass-loss Rates for Sun-like Stars: A Hybrid Model Approach

The Astrophysical Journal, 2023
We observe an enhanced stellar wind mass-loss rate from low-mass stars exhibiting higher X-ray flux. This trend, however, does not align with the Sun, where no evident correlation between X-ray flux and mass-loss rate is present.
Munehito Shoda, Steven R. Cranmer, Shin Toriumi   +2 more
doaj   +1 more source

A Semi-empirical Mass-loss Rate in Short-period Cataclysmic Variables

, 2010
The mass-loss rate of donor stars in cataclysmic variables (CVs) is of paramount importance in the evolution of short-period CVs. Observed donors are oversized in comparison with those of isolated single stars of the same mass, which is thought to be a ...
Andronov, Baraffe, Chandrasekhar, Chandrasekhar, Fedir V. Sirotkin, Howell, King, Kippenhahn, Kopal, Landau, Paczynski, Patterson, Ritter, Ritter, Sirotkin, Soberman, Stehle, Townsley, Townsley, Townsley, Urban, Woong-Tae Kim   +21 more
core   +1 more source

Mass-Loss Rate Determination for the Massive Binary V444 Cyg using 3-D Monte-Carlo Simulations of Line and Polarization Variability [PDF]

, 2002
A newly developed 3-D Monte Carlo model is used, in conjunction with a multi-line non-LTE radiative transfer model, to determine the mass-loss rate of the Wolf-Rayet (W-R) star in the massive binary \object{V444 Cyg} (WN5+O6).
Abbott, Bartzakos, Beals, Blondin, Brown, Canto, Castor, Cherepashchuk, Cherepashchuk, Cherepashchuk, Corcoran, D. J. Hillier, Forbes, Gayley, Girard, Hamann, Hamann, Hartmann, Herald, Hillier, Hillier, Hillier, Howarth, Howarth, Huang, J. M. Pittard, Khaliullin, Kron, Kuhi, Kurosawa, Lamontagne, Leitherer, Lundström, Luo, Lührs, Maeda, Marchenko, Marchenko, Meynet, Moffat, Myasnikov, Münch, Najarro, Nugis, Pittard, Pittard, Pittard, Prinja, R. Kurosawa, Robert, Schmutz, Shore, St-Louis, St-Louis, Stevens, Stevens, Stevens, Stevens, Underhill, Underhill, Usov, Usov, van der Hucht, Vanbeveren, Vishniac, Vishniac, Wilson, Wolf, Wright   +68 more
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Mass loss rates of a sample of irregular and semiregular M-type AGB-variables [PDF]

, 2002
We have determined mass loss rates and gas expansion velocities for a sample of 69 M-type irregular (IRV; 22 objects) and semiregular (SRV; 47 objects) AGB-variables using a radiative transfer code to model their circumstellar CO radio line emission.
Arndt, Barthès, Bergman, Bernes, Chandra, Crosas, D. González Delgado, Doty, Elitzur, F. Kerschbaum, F. L. Schöier, Flower, Flower, Glassgold, Groenewegen, Groenewegen, Groenewegen, H. Olofsson, Habing, Habing, Hale, Huggins, Huggins, Höfner, Jura, Kahane, Kahane, Kahane, Kastner, Kerschbaum, Kerschbaum, Kerschbaum, Kerschbaum, Kerschbaum, Knapp, Knapp, Kwan, Kwok, Lindqvist, Lindqvist, Mamon, Marengo, Mauron, Netzer, Neufeld, Olofsson, Olofsson, Olofsson, Olofsson, Ryde, Ryde, Schinke, Schöier, Schöier, van Langevelde, Winters, Young   +56 more
core   +3 more sources