Results 61 to 70 of about 2,282,439 (313)

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Preferences for body mass index and waist-to-hip ratio do not vary with observer age

open access: yes, 2008
. Several studies have suggested that mate selection strategies alter with age, but the mechanism of this shift in mate strategy is unclear. Two possibilities suggest themselves. The first is that attractiveness preferences themselves alter, compensating
Swami, V.   +9 more
core   +1 more source

Isotope ratio mass spectrometry application for environmental investigations [PDF]

open access: yesE3S Web of Conferences, 2019
Stable isotope ratio mass spectrometry (IRMS) is a useful technique with a broad range of applications. Stable isotopes are important indicators of environmental changes (including climate), and can be used to explain the functioning of biogeochemical ...
Simonova Galina, Kalashnikova Daria
doaj   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

mass distribution ratio

open access: yes, 2014
Citation: 'mass distribution ratio' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.MT06929 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms. Requests for
  +4 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Experimental investigation of two-degree-freedom VIV of circular cylinder with low equivalent mass and variable natural frequency ratio

open access: yes, 2013
This contribution looks at an experimental investigation of two-degree-freedom VIV of circular cylinder with low equivalent mass and variable natural frequency ...
Day, Alexander   +5 more
core   +1 more source

A Study on the Two-Dimensional Numerical Simulation of Wing Flutter in a Heavy Gas

open access: yesAerospace
Using heavy gases in wind tunnel tests can reduce model weight issues, which have intensified with advancements in high-performance aircraft technology. This study employs time-domain analysis to examine the flutter characteristics and correction methods
Zhe Hu, Shun He, Bo Lu, Jun Zha
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

An Extremely Low Mass Ratio Binary at the Key Stage of Evolution

open access: yesGalaxies
This study presents multi-band photometric observations and detailed period analysis of a totally eclipsing binary system exhibiting low photometric amplitude.
Fen Liu   +5 more
doaj   +1 more source

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