Results 111 to 120 of about 907,448 (315)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Estimating the long-term effects of mass screening for latent and active tuberculosis in the Marshall Islands. [PDF]

Int J Epidemiol, 2022
Ragonnet R, Williams BM, Largen A, Nasa J, Jack T, Langinlur MK, Ko E, Rahevar K, Islam T, Denholm JT, Marais BJ, Marks GB, McBryde ES, Trauer JM.   +13 more
europepmc   +1 more source

A rapid screening method for prenylated flavonoids with ultra‐high‐performance liquid chromatography/electrospray ionisation mass spectrometry in licorice root extracts

, 2009
R. G. Simons, Jean‐Paul Vincken, Edwin J. Bakx, M.A. Verbruggen, Harry Gruppen   +4 more
openalex   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A machine learning COVID-19 mass screening based on symptoms and a simple olfactory test. [PDF]

Sci Rep, 2022
Azeli Y, Fernández A, Capriles F, Rojewski W, Lopez-Madrid V, Sabaté-Lissner D, Serrano RM, Rey-Reñones C, Civit M, Casellas J, El Ouahabi-El Ouahabi A, Foglia-Fernández M, Sarrá S, Llobet E.   +13 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Regression model for predicting core body temperature in infrared thermal mass screening. [PDF]

IPEM Transl, 2022
Limpabandhu C, Hooper FSW, Li R, Tse Z.
europepmc   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

A Push for Real Normal: Mass Screening for COVID-19. [PDF]

Clin Chem, 2021
Poon LLM.
europepmc   +1 more source

Mass screening for asymptomatic SARS-CoV-2 infection [PDF]

, 2021
Angela E. Raffle, Michael Gill
openalex   +1 more source