Power and limitations of electrophoretic separations in proteomics strategies [PDF]
Proteomics can be defined as the large-scale analysis of proteins. Due to the complexity of biological systems, it is required to concatenate various separation techniques prior to mass spectrometry.
Aebersold+225 more
core +3 more sources
A Cross-platform Toolkit for Mass Spectrometry and Proteomics
Mass-spectrometry-based proteomics has become an important component of biological research. Numerous proteomics methods have been developed to identify and quantify the proteins in biological and clinical samples1, identify pathways affected by ...
Matthew Chambers+42 more
semanticscholar +1 more source
Identifying metabolites by integrating metabolome databases with mass spectrometry cheminformatics. [PDF]
Novel metabolites distinct from canonical pathways can be identified through the integration of three cheminformatics tools: BinVestigate, which queries the BinBase gas chromatography-mass spectrometry (GC-MS) metabolome database to match unknowns with ...
A El-Tayeb+45 more
core +1 more source
Beyond mass spectrometry, the next step in proteomics
This survey illuminates alternatives for sequencing proteins with the brightest prospects for displacing mass spectrometry. Proteins can be the root cause of a disease, and they can be used to cure it.
W. Timp, G. Timp
semanticscholar +1 more source
Pitfall in the high-throughput quantification of whole blood cyclosporin A using liquid chromatography-tandem mass spectrometry [PDF]
In a growing number of laboratories the technique of liquid chromatography-tandem mass spectrometry is used for the quantification of cyclosporin A in whole blood, employing cyclosporin D as the internal standard. Cyclosporin A is extensively metabolized
Spöhrer, Ute, Vogeser, Michael
core +1 more source
Laser-cooling-assisted mass spectrometry
Mass spectrometry is used in a wide range of scientific disciplines including proteomics, pharmaceutics, forensics, and fundamental physics and chemistry.
Chen, Kuang+4 more
core +1 more source
Machine Learning Applications for Mass Spectrometry-Based Metabolomics
The metabolome of an organism depends on environmental factors and intracellular regulation and provides information about the physiological conditions.
Ulf W. Liebal+4 more
semanticscholar +1 more source
Multiplierz: An Extensible API Based Desktop Environment for Proteomics Data Analysis [PDF]
BACKGROUND. Efficient analysis of results from mass spectrometry-based proteomics experiments requires access to disparate data types, including native mass spectrometry files, output from algorithms that assign peptide sequence to MS/MS spectra, and ...
Askenazi, Manor+7 more
core +4 more sources
Frozen section analysis is a frequently used method for examination of tissue samples, especially for tumour detection. In the majority of cases, the aim is to identify characteristic tissue morphologies or tumour margins. Depending on the type of tissue,
Tim Kümmel+8 more
doaj +1 more source
Characterization and Quantification of Isoprene-Derived Epoxydiols in Ambient Aerosol in the Southeastern United States [PDF]
Isoprene-derived epoxydiols (IEPOX) are identified in ambient aerosol samples for the first time, together with other previously identified isoprene tracers (i.e., 2-methyltetrols, 2-methylglyceric acid, C5-alkenetriols, and organosulfate derivatives of ...
Chan, Man Nin+10 more
core +2 more sources