Results 71 to 80 of about 1,203,401 (307)
A cosmogenic 10Be anomaly during the late Miocene as independent time marker for marine archives
Nature CommunicationsCosmogenic nuclide dating relies on the constancy of production and incorporation of radionuclides in geological archives. Anomalous deviations from constancy during the Holocene or Pleistocene are frequently used as global benchmarks to harmonize ...
Dominik Koll +9 more
doaj +1 more source
Journal of Lipid Research, 1991 Free vulpecholic acid (1 alpha,3 alpha,7 alpha-trihydroxy-5 beta-cholan-24-oic) is the major biliary component of the Australian opossum (Trichosurus vulpecula), accompanied only by a few percent of its taurine conjugate.
J St Pyrek +4 more
doaj +1 more source
Defensive functions and potential ecological conflicts of floral stickiness
Scientific Reports, 2022 Stickiness of vegetative tissues has evolved multiple times in different plant families but is rare and understudied in flowers. While stickiness in general is thought to function primarily as a defense against herbivores, it may compromise mutualistic ...
Alexander Chautá +4 more
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Identification of a Widespread Palmitoylethanolamide Contamination in Standard Laboratory Glassware. [PDF]
, 2017 Introduction: Fatty acid ethanolamides (FAEs) are a family of lipid mediators that participate in a host of biological functions. Procedures for the quantitative analysis of FAEs include organic solvent extraction from biological matrices (e.g., blood ...
Angelini, Roberto +3 more
core
Detection of metastable electronic states by Penning trap mass spectrometry
, 2020 State-of-the-art optical clocks achieve fractional precisions of $10^{-18}$ and below using ensembles of atoms in optical lattices or individual ions in radio-frequency traps.
Bekker, Hendrik +21 more
core +2 more sources
Coulomb crystal mass spectrometry in a digital ion trap [PDF]
, 2015 We present a mass spectrometric technique for identifying the masses and relative abundances of Coulomb-crystallized ions held in a linear Paul trap.
Deb, Nabanita +6 more
core +2 more sources
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Scientific Reports, 2018 Cardiovascular diseases are often associated with impaired lipid metabolism. Animal models are useful for deciphering the physiological mechanisms underlying these pathologies.
Zied Kaabia +9 more
doaj +1 more source
A streamlined pipeline for multiplexed quantitative site-specific N-glycoproteomics
Nature Communications, 2020 Comprehensive quantitative profiling of intact glycopeptides remains technically challenging. To address this, the authors here develop an integrated quantitative glycoproteomic workflow, including optimized sample preparation, multiplexed quantification
Pan Fang +8 more
doaj +1 more source