Results 101 to 110 of about 610,359 (296)

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

open access: yesMolecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi   +12 more
wiley   +1 more source

Regge trajectories and mass spectrum of heavy tetraquarks

open access: yesEuropean Physical Journal C: Particles and Fields
In this work, we calculated the masses of the ground and radial excited states of heavy tetraquarks in the framework of the nonrelativistic quark model for two wave states nS and nP.
A. Ghasempour, N. Tazimi, M. Monemzadeh
doaj   +1 more source

A graph-based filtering method for top-down mass spectral identification

open access: yesBMC Genomics, 2018
Background Database search has been the main approach for proteoform identification by top-down tandem mass spectrometry. However, when the target proteoform that produced the spectrum contains post-translational modifications (PTMs) and/or mutations, it
Runmin Yang, Daming Zhu
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Mass spectrum & linear perturbations of ghost-free multi-spin-2 theory

open access: yesJournal of High Energy Physics
Motivated by the spin-2 nature of gravity, we consider a theory of N $$ \mathcal{N} $$ interacting spin-2 fields, formulated in terms of vielbeins, which has been argued to be free of Boulware-Deser ghost instabilities. This is the only known such theory
J. Flinckman, S. F. Hassan
doaj   +1 more source

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