Results 101 to 110 of about 2,270,482 (341)

The quest for the neutrino mass spectrum [PDF]

, 2000
This article provides a (semi-)popular introduction to the phenomenology of neutrino masses.Comment: 19 pages, 6 ...
Klapdor-Kleingrothaus, H. V., Päs, H.
core   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

A spectral differential characterization of low-mass companions

EPJ Web of Conferences, 2013
We present a new approach with which the dynamical mass of low-mass companions around cool stars can be found. In order to discover companions to late-type stars the stellar spectrum is removed.
Lyubchik Y., Yakobchuk T., Kostogryz N., Kürster M., Kuznetsov M.   +4 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source

Metabolomics and molecular networking approach for exploring the anti-diabetic activity of medicinal plants. [PDF]

RSC Adv, 2023
Timilsina AP, Raut BK, Huo C, Khadayat K, Budhathoki P, Ghimire M, Budhathoki R, Aryal N, Kim KH, Parajuli N.   +9 more
europepmc   +1 more source

On the Effective Mass of the Electron Neutrino in Beta Decay

, 2002
In the presence of mixing between massive neutrino states, the distortion of the electron spectrum in beta decay is, in general, a function of several masses and mixing angles.
A.Yu. Smirnov, Achkar, Barenboim, Barenboim, Barenboim, Barenboim, Boehm, Bonn, Farzan, Feruglio, Grimus, Lobashev, Lobashev, Lobashev, Maltoni, Maltoni, Murayama, Osipowicz, Pas, Shrock, Studnik, Vissani, Vissani, Y. Farzan   +23 more
core   +4 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Inferring the Nominal Molecular Mass of an Analyte from Its Electron Ionization Mass Spectrum. [PDF]

Anal Chem, 2023
Moorthy AS, Kearsley AJ, Mallard WG, Wallace WE, Stein SE.   +4 more
europepmc   +1 more source