Results 81 to 90 of about 2,270,482 (341)

A proteomic approach based on peptide affinity chromatography, 2-dimensional electrophoresis and mass spectrometry to identify multiprotein complexes interacting with membrane-bound receptors

open access: yesBiological Procedures Online, 2002
There is accumulating evidence that membrane-bound receptors interact with many intracellular proteins. Multiprotein complexes associated with ionotropic receptors have been extensively characterized, but the identification of proteins interacting with G
Bécamel Carine   +6 more
doaj   +1 more source

Bound Electron Enhanced Radiosensitisation of Nimorazole upon Charge Transfer

open access: yesMolecules, 2022
This novel work reports nimorazole (NIMO) radiosensitizer reduction upon electron transfer in collisions with neutral potassium (K) atoms in the lab frame energy range of 10–400 eV.
Sarvesh Kumar   +4 more
doaj   +1 more source

A model-independent confirmation of the $Z(4430)^-$ state [PDF]

open access: yes, 2015
The decay $B^0\to \psi(2S) K^+\pi^-$ is analyzed using $\rm 3~fb^{-1}$ of $pp$ collision data collected with the LHCb detector. A model-independent description of the $\psi(2S) \pi$ mass spectrum is obtained, using as input the $K\pi$ mass spectrum and ...
Aaij, R.   +727 more
core   +5 more sources

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Relativistic description of the charmonium mass spectrum

open access: yes, 2005
The charmonium mass spectrum is considered in the framework of the constituent quark model with the relativistic treatment of the c quark. The obtained masses are in good agreement with the existing experimental data including the mass of eta_c(2S ...
Badalian A. M.   +7 more
core   +1 more source

Update of the Hagedorn mass spectrum [PDF]

open access: yesPhysical Review D, 2004
4 pages, 4 ...
Wojciech Broniowski   +2 more
openaire   +3 more sources

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

open access: yesMolecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton   +17 more
wiley   +1 more source

Multi-Higgs Mass Spectrum in Gauge-Higgs Unification

open access: yes, 2008
We study an SU(2) supersymmetric gauge model in a framework of gauge-Higgs unification. Multi-Higgs spectrum appears in the model at low energy. We develop a useful perturbative approximation scheme for evaluating effective potential to study the multi ...
Kazunori Takenaga   +6 more
core   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

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