Results 81 to 90 of about 2,087,811 (325)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Critical collapse and the primordial black hole initial mass function [PDF]

, 1999
It has normally been assumed that primordial black holes (PBHs) always form with mass approximately equal to the mass contained within the horizon at that time.
A. M. Green, A. R. Liddle, Andrew R. Liddle, Anne M. Green, B. J. Carr, B. J. Carr, B. J. Carr, C. Alcock, C. Gundlach, C. Lacey, C. Lacey, C. Porciani, C. R. Evans, C. Schmid, C. Schmid, J. C. Niemeyer, J. C. Niemeyer, J. Garcá-Bellido, J. R. Bond, J. S. Bullock, J. Yokoyama, K. Jedamzik, L. Randall, M. Crawford, M. W. Choptuik, P. Ivanov, P. Ivanov   +26 more
core   +2 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Update of the Hagedorn mass spectrum [PDF]

Physical Review D, 2004
4 pages, 4 ...
Wojciech Broniowski, Wojciech Florkowski, Leonid Ya. Glozman   +2 more
openaire   +3 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Soft breaking of $L_\mu-L_\tau$ symmetry: Light neutrino spectrum and Leptogenesis

, 2006
Continuous $U(1)_{L_\mu-L_\tau}$ symmetry can generate quasi degenerate mass spectrum for both left handed light and right handed heavy Majorana neutrinos assuming that the symmetry preserving non zero parameters are nearly same. There is an accidental $\
B. Pontecorvo, B. Pontecorvo, B. Pontecorvo, B. Pontecorvo, Biswajit Adhikary, E. A. Paschos, E. W. Kolb, J. N. Abdurashitov, M. Flanz, M. Roos, R. N. Mohapatra, R. N. Mohapatra, W. Buchmuller, W. Grimus   +13 more
core   +2 more sources

Automated mass spectrum generation for new physics [PDF]

, 2013
We describe an extension of the FeynRules package dedicated to the automatic generation of the mass spectrum associated with any Lagrangian-based quantum field theory.
Alloul, Adam, D'Hondt, Jorgen, De Causmaecker, Karen, de Traubenberg, Michel Rausch, Fuks, Benjamin   +4 more
core   +2 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

New sialic acid-containing sulfolipid: “ungulic acid”

Journal of Lipid Research, 1969
Human epidermis, hair, nails, and kidney as well as bovine and horses' hooves were found to contain a lipid fraction, which on thin-layer chromatography migrated slightly ahead of the cerebroside sulfate esters and gave the color reaction specific for ...
E. Leikola, Elna Nieminen, Anna-Maija Teppo   +2 more
doaj  

Mass Spectrum of Mesons via the WKB Approximation Method

Advances in High Energy Physics, 2020
In this paper, we demonstrated that the multiple turning point problems within the framework of the Wentzel-Kramers-Brillouin (WKB) approximation method can be reduced to two turning point one for a nonsymmetric potential function by using an appropriate
Ekwevugbe Omugbe, Omosede E. Osafile, Michael C. Onyeaju   +2 more
doaj   +1 more source