Results 91 to 100 of about 2,871,177 (303)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
A Method of Calculating a Time-Varying Volume of Combustion Products in the Cylindrical Chamber
Механика машин, механизмов и материалов, 2008 A method of calculating a volume of combustion products when a flame spreads in the closed cylindrical chamber is developed, assuming that the front is spherical for two positions of an ignition source: at the end (central ignition) and cylindrical (side
M.S. Assad +2 more
doaj
Investigation of the regularities of vortical flows in a cyclone-bed chamber
Весці Нацыянальнай акадэміі навук Беларусі: Серыя фізіка-тэхнічных навук, 2018 Experimental investigation of the radial distributions of tangential and longitudinal velocities, total and static pressures in the vortex zone of a cyclone-bed chamber of diameter 0.21 m has been carried out.
E. A. Pitsukha +2 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Implications for the Formation of Blue Straggler Stars from HST Ultraviolet Observations of NGC 188
, 2015 We present results of a Hubble Space Telescope far-ultraviolet (FUV) survey searching for white dwarf (WD) companions to blue straggler stars (BSSs) in open cluster NGC 188.
Geller, Aaron M. +5 more
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Весці Нацыянальнай акадэміі навук Беларусі: Серыя фізіка-тэхнічных навукThe results of studies on the production of a porous ceramic-matrix composite material C–N/SiC from silicon carbide and nitrogen-doped nanostructured carbon for subsequent use as supercapacitor electrodes are presented. The material is formed by pressing
D. V. Solovei +3 more
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Механика машин, механизмов и материаловThis article presents the results that have provided a methodical basis for designing a digital twins of the main oil line and injectors of the lubrication system of a diesel engine.
Andrei D. Chorny +5 more
doaj +1 more source