Results 101 to 110 of about 2,277,334 (290)
Transport Characteristics of Small Molecules Diffusing near Deforming Blood Cells
ComputationUnderstanding the transport of small molecules such as oxygen in biological systems requires knowledge about how molecules dynamically interact with these molecules.
Stephanie Nix
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
ChemElectroChemHydrogen transport in the anode of a proton‐exchange membrane fuel cell (PEMFC) has been studied with a modulation technique relating the hydrogen flow‐rate ( Q˜H2 ) and the faradaic current ( I˜ ), called Current‐modulated Hydrogen flow‐rate ...
Luis Duque +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Enhanced Oil Recovery by Polymer Flooding: Direct, Low-Cost Visualization in a Hele–Shaw Cell
Education Sciences, 2019 We designed a hands-on laboratory exercise to demonstrate why injecting an aqueous polymer solution into an oil reservoir (commonly known as “polymer flooding”) enhances oil production.
Yukie Tanino, Amer Syed
doaj +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Liquid Crystal‐Driven Chemical Feeding Accelerates Condensation Reactions in Droplet Microreactors
Advanced ScienceDroplet microreactors have gained significant attention as confined spaces for chemical reactions, offering enhanced reaction rates and control. However, the impact of mass transfer induced by chemical feeding within these microreactors remains largely ...
Yang Xu +5 more
doaj +1 more source
Human pluripotent NT2/D1 cells immobilized in alginate microfibers: A 3D system for testing the effects of bioactive compounds [PDF]
Hemijska IndustrijaExtensive consumption of energy drinks (ED) and alcohol mixed with energy drinks (AmED) has become a prevalent practice among young people. Marked as enhancers of physical and mental performance due to their high levels of stimulant ingredients, such as ...
Pejić Jelena Lj. +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source