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Mast Cell Disorders

The Journal of Allergy and Clinical Immunology: In Practice, 2016
ivision of Allergy, Immunology and Rheumatology, Department of Pediatrics, Morgan Stanley Children’s Hospital-New York Presbyterian, Columbia University Medical Center, New York, NY astocytosis Center, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Mass nflicts of ...
Joyce E, Yu, Cem, Akin
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Mast cell biology

Journal of Allergy and Clinical Immunology, 1990
Mast cells are the repository for histamine in the body. They influence the pathophysiology of allergic diseases, such as rhinitis, urticaria, and asthma; regulate bone formation and integrity; help repair and maintain connective tissue; promote wound healing; and probably contribute to the development and preservation of the endothelium and small ...
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Mast Cell Heterogeneity

Trends in Pharmacological Sciences, 1983
Most allergic disorders are now recognized to be complex inflammatory processes involving the participation of a number of different cell types. Of these, the mast cell has assumed a pre-eminent position both because of its ability to release a diversity of spasmogenic, chemotactic and inflammatory mediators, and in view of its strategic location at ...
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Targeting mast cells

Expert Opinion on Investigational Drugs, 2004
Mast cells play a key role in the induction of allergic disorders, such as asthma and rhinitis, through the release of mediators including histamine, arachidonate products, proteases and several cytokines, which are found in relatively high quantities in these cells.
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Mast Cell Apoptosis

2005
Apoptosis is a physiological form of cell death. Cells undergoing apoptosis execute a genetically controlled program that leads to organized breakdown of cellular structures and ends in phagocytosis of their remains. In mast cells, several mechanisms regulating apoptosis have been identified including growth factors, tumor necrosis factor-alpha ...
Alexander, Gerbaulet   +2 more
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Human mast cell proteases and mast cell heterogeneity

Current Opinion in Immunology, 1988
Mast cell neutral proteases are distinctive markers of the MC(T) and MC(TC) cells in humans. Measurements of tryptase levels in vivo serve as an overall indicator of mast cell activity. Further research is needed to evaluate the functional role of these proteases as well as each mast cell type in situations related to both health and disease.
J S, Miller, L B, Schwartz
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TISSUE MAST CELLS

Journal of the American Medical Association, 1960
During the past few years much information has accumulated concerning the physiological and pathological significance of tissue mast cells. It is more than of historical interest to note that these cells were first clearly described by Ehrlich in 1878.
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Mast Cell Disease

Allergy and Asthma Proceedings, 1992
The mast cell, equipped with enzymes, chemotactic factors, a vasoactive amine, an anticoagulant, and lipid-derived proinflammatory products, may be essential in tissue modeling as well as in defense. Its primarily perivascular location in skin and the mucosa of the respiratory tract and the gut assures its availability to counter parasites. By the same
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Mast cell–T cell interactions

Journal of Allergy and Clinical Immunology, 1999
In addition to being a major effector cell in the elicitation of allergic inflammation, mast cells have been found to be activated in various T cell-mediated inflammatory processes and to reside in close physical proximity to T cells. Such observations and the wide spectrum of mediators produced and secreted by mast cells have led investigators to ...
Y A, Mekori, D D, Metcalfe
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Mast Cell Pleomorphism: Properties of Intestinal Mast Cells

1987
Consistent with their nearly ubiquitous distribution throughout the body, mast cells interact with a variety of cell types and react to numerous environmental stimuli. They can be activated by macrophage (1) and T cell factors (2), by complement fragments, as well as by IgE-allergen interactions.
M, Swieter   +4 more
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