Results 11 to 20 of about 77,966 (263)

Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-α-PD-L1 pathway

Journal for ImmunoTherapy of Cancer, 2019
Background Mast cells are prominent components of solid tumors and exhibit distinct phenotypes in different tumor microenvironments. However, the nature, regulation, function, and clinical relevance of mast cells in human gastric cancer (GC) are ...
Yipin Lv, Yongliang Zhao, Xianhua Wang, Na Chen, Fangyuan Mao, Yongsheng Teng, Tingting Wang, Liusheng Peng, Jinyu Zhang, Ping Cheng, Yugang Liu, Hui Kong, Weisan Chen, Chuanjie Hao, Bin Han, Qiang Ma, Quanming Zou, Jun Chen, Yuan Zhuang   +18 more
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Prognostic significance of mast cells and vascular density in prostatic adenocarcinoma

Indian Journal of Pathology and Microbiology, 2022
Context: Though mast cells infiltrate solid tumors, the exact role of mast cells in tumor biology is controversial. Mast cell density (MCD) may vary depending on its location in the tumor and tumor vascularity. MCD may influence the tumor aggressiveness.
Bismay Das, Susan M Mendonca
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Modeling Pharmacological Inhibition of Mast Cell Degranulation as a Therapy for Insulinoma

Neoplasia: An International Journal for Oncology Research, 2011
Myc, a pleiotropic transcription factor that is deregulated and/or overexpressed in most human cancers, instructs multiple extracellular programs that are required to sustain the complex microenvironment needed for tumor maintenance, including remodeling
Laura Soucek, Joseph J. Buggy, Roderik Kortlever, Shanthi Adimoolam, Helena Allende Monclús, Maria Teresa Salcedo Allende, Lamorna Brown Swigart, Gerard I. Evan   +7 more
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A study on mast cell variation in neoplastic and non neoplastic disease of uterine cervix

Journal of Pathology of Nepal, 2014
Background: Mast cells are heterogeneous group of immune cells involved in multiple biological events. The significance of mast cells in uterine tumor surveillance has been studied with conflicting results.
N Mainali, AK Sihna, P Upadhyaya, D Upreti   +3 more
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Case Report: Molecular and microenvironment change upon midostaurin treatment in mast cell leukemia at single-cell level

Frontiers in Immunology, 2023
Mast cell leukemia is a rare and aggressive disease, predominantly with KIT D816V mutation. With poor response to conventional poly-chemotherapy, mast cell leukemia responded to the midostaurin treatment with a 50% overall response rate (ORR), but ...
Meng-Ke Liu, Feng Liu, Yu-Ting Dai, Xiang-Qin Weng, Li-Li Cheng, Li-Quan Fan, Han Liu, Lu Jiang, Xiao-Jian Sun, Hai Fang, Li Wang, Wei-Li Zhao   +11 more
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A transcriptomic insight into the impacts of mast cells in lung, breast, and colon cancers

OncoImmunology, 2017
To date, the exact impact of mast cells in tumor microenvironment is still controversial because of inconsistency in observations regarding the relationship between mast cell infiltrates and cancer development and prognosis. The discrepancies in previous
Eun-A Ko, Kenton M. Sanders, Tong Zhou
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Characterization of WWOX expression and function in canine mast cell tumors and malignant mast cell lines

BMC Veterinary Research, 2020
Background The WW domain-containing oxidoreductase (WWOX) tumor suppressor gene is frequently lost in a variety of solid and hematopoietic malignancies in humans. Dysregulation of WWOX has been implicated as playing a key role in tumor cell survival, DNA
Rebecca Makii, Hanna Cook, Darian Louke, Justin Breitbach, Ryan Jennings, Christopher Premanandan, Eric M. Green, Joelle M. Fenger   +7 more
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Large-scale bulk RNA-seq analysis defines immune evasion mechanism related to mast cell in gliomas

Frontiers in Immunology, 2022
Accumulating evidence has demonstrated that the immune cells have an emerging role in controlling anti-tumor immune responses and tumor progression. The comprehensive role of mast cell in glioma has not been illustrated yet.
Rui Chen, Wantao Wu, Wantao Wu, Wantao Wu, Tao Liu, Tao Liu, Tao Liu, Yihan Zhao, Yihan Zhao, Yihan Zhao, Yifan Wang, Yifan Wang, Hao Zhang, Hao Zhang, Zeyu Wang, Zeyu Wang, Ziyu Dai, Ziyu Dai, Xiaoxi Zhou, Xiaoxi Zhou, Peng Luo, Jian Zhang, Zaoqu Liu, Li-Yang Zhang, Li-Yang Zhang, Quan Cheng, Quan Cheng   +26 more
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Solitary mast cell tumor of the lung [PDF]

Cancer, 1988
An extremely rare solitary mast cell tumor of the lung was studied histologically, immunohistochemically, and ultrastructurally. The histologic features of the tumor included nodular growth of well-differentiated mast cells and clear cells with no granules.
H, Kudo, S, Morinaga, Y, Shimosato, M, Noguchi, Y, Mizutani, H, Asamura, T, Naruke   +6 more
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Diagnosis, Prognosis and Treatment of Canine Cutaneous and Subcutaneous Mast Cell Tumors

Cells, 2022
Mast cell tumors (MCTs) are hematopoietic neoplasms composed of mast cells. It is highly common in dogs and is extremely important in the veterinary oncology field.
Andrigo Barboza de Nardi, Rodrigo dos Santos Horta, Carlos Eduardo Fonseca-Alves, Felipe Noleto de Paiva, Laís Calazans Menescal Linhares, Bruna Fernanda Firmo, Felipe Augusto Ruiz Sueiro, Krishna Duro de Oliveira, Silvia Vanessa Lourenço, Ricardo De Francisco Strefezzi, Carlos Henrique Maciel Brunner, Marcelo Monte Mor Rangel, Paulo Cesar Jark, Jorge Luiz Costa Castro, Rodrigo Ubukata, Karen Batschinski, Renata Afonso Sobral, Natália Oyafuso da Cruz, Adriana Tomoko Nishiya, Simone Crestoni Fernandes, Simone Carvalho dos Santos Cunha, Daniel Guimarães Gerardi, Guilherme Sellera Godoy Challoub, Luiz Roberto Biondi, Renee Laufer-Amorim, Paulo Ricardo de Oliveira Paes, Gleidice Eunice Lavalle, Rafael Ricardo Huppes, Fabrizio Grandi, Carmen Helena de Carvalho Vasconcellos, Denner Santos dos Anjos, Ângela Cristina Malheiros Luzo, Julia Maria Matera, Miluse Vozdova, Maria Lucia Zaidan Dagli   +34 more
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