Results 21 to 30 of about 77,966 (263)

Tumor microvessel density–associated mast cells in canine nodal lymphoma

SAGE Open Medicine, 2014
Objective: Mast cells are associated in angiogenesis in various human and animal neoplasms. However, association of mast cells with tumor microvessel density in canine lymphoma was not previously documented.
Moges Woldemeskel, Elizabeth Mann, Lisa Whittington   +2 more
doaj   +1 more source

Although Abundant in Tumor Tissue, Mast Cells Have No Effect on Immunological Micro-milieu or Growth of HPV-Induced or Transplanted Tumors

Cell Reports, 2018
Summary: High numbers of mast cells populate the stroma of many types of neoplasms, including human papilloma virus-induced benign and malignant tumors in man and mouse.
Shanawaz Mohammed Ghouse, Anastasia Polikarpova, Lina Muhandes, Jan Dudeck, Iliana Tantcheva-Poór, Karin Hartmann, Matthias Lesche, Andreas Dahl, Sabine Eming, Werner Müller, Rayk Behrendt, Axel Roers   +11 more
doaj   +1 more source

Identification of Mast Cell-Based Molecular Subtypes and a Predictive Signature in Clear Cell Renal Cell Carcinoma

Frontiers in Molecular Biosciences, 2021
Background: Kidney renal clear cell carcinoma (KIRC) is a common malignant tumor of the urinary system. Surgery is the preferred treatment option; however, the rate of distant metastasis is high.
Hanxiang Liu, Yi Yang
doaj   +1 more source

Intratumoral and Peritumoral Mast Cells in Malignant Melanoma: An Immunohistochemical Study

Advanced Biomedical Research, 2017
Background: The aim of the current study was to determine mast cell infiltration in malignant melanoma by immunohistochemistry method and its relationship with some of the cancer prognostic factors, including age, sex, and depth of the tumor.
Parvin Rajabi, Azam Bagheri, Mohssen Hani   +2 more
doaj   +1 more source

CTSG-expressing mast cells confer resistance to immunotherapy in colorectal cancer

Frontiers in Oncology
BackgroundMast cells are increasingly recognized as an important regulator of the tumor microenvironment. However, their role in colorectal cancer (CRC) is controversial, and there is a lack of targetable mast cell-specific molecules to improve the tumor
Xuehui Jiang, Runsheng Hong, Zilin Liu, Chao Zhong, Chao Zhong, Yun Dai   +5 more
doaj   +1 more source

Distribution of Mast Cells in Mediastinal Lymph Nodes from Lung Cancer Patients

World Journal of Surgical Oncology, 2003
Background Mast cells have been documented to have several key functions with regards to malignant neoplasms. However, the functional significance of their accumulation is largely unknown.
Shimizu Tetsuya, Edagawa Masao, Matsuzaki Yasunori, Tomita Masaki, Hara Masaki, Onitsuka Toshio   +5 more
doaj   +1 more source

Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non‐small cell lung cancer

Cancer Reports, EarlyView., 2023
Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada, Mitsuhiro Isaka, Akira Ono, Takuya Kawata, Masakuni Serizawa, Keita Mori, Koji Muramatsu, Kiyoshi Tone, Hirotsugu Kenmotsu, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Masatoshi Kusuhara, Yasuto Akiyama, Takashi Sugino, Toshiaki Takahashi, Yasuhisa Ohde   +16 more
wiley   +1 more source

Intratumor IL-17-positive mast cells are the major source of the IL-17 that is predictive of survival in gastric cancer patients. [PDF]

PLoS ONE, 2014
Interleukin-17 (IL-17) is prevalent in tumor tissue and suppresses effective anti-tumor immune responses. However, the source of the increased tumor-infiltrating IL-17 and its contribution to tumor progression in human gastric cancer remain poorly ...
Xiaosun Liu, Hailong Jin, Geer Zhang, Xianke Lin, Chao Chen, Jianyi Sun, Yu Zhang, Qing Zhang, Jiren Yu   +8 more
doaj   +1 more source

Mast Cells as a Target—A Comprehensive Review of Recent Therapeutic Approaches

Cells, 2023
Mast cells (MCs) are the immune cells distributed throughout nearly all tissues, mainly in the skin, near blood vessels and lymph vessels, nerves, lungs, and the intestines.
Joanna Baran, Anna Sobiepanek, Anna Mazurkiewicz-Pisarek, Marta Rogalska, Aleksander Gryciuk, Lukasz Kuryk, Soman N. Abraham, Monika Staniszewska   +7 more
doaj   +1 more source

Recent advances in the understanding and therapeutic management of mastocytosis [version 1; peer review: 4 approved]

F1000Research, 2019
Mastocytosis is a rare disease due to the abnormal accumulation of mast cells in various tissues. Its clinical presentation is heterogeneous depending on mast cell infiltration and mediators release.
Julien Rossignol, Laura Polivka, Leila Maouche-Chrétien, Laurent Frenzel, Patrice Dubreuil, Olivier Hermine   +5 more
doaj   +1 more source