Results 91 to 100 of about 175,673 (317)

Polo-like kinase-1 as a novel target in neoplastic mast cells: demonstration of growth-inhibitory effects of small interfering RNA and the Polo-like kinase-1 targeting drug BI 2536

Haematologica, 2011
Background In advanced systemic mastocytosis the response of neoplastic mast cells to conventional drugs is poor and the prognosis is bad. Current research is, therefore, attempting to identify novel drug targets in neoplastic mast cells.
Barbara Peter, Karoline V. Gleixner, Sabine Cerny-Reiterer, Harald Herrmann, Viviane Winter, Emir Hadzijusufovic, Veronika Ferenc, Karina Schuch, Irina Mirkina, Hans-Peter Horny, Winfried F. Pickl, Leonhard Müllauer, Michael Willmann, Peter Valent   +13 more
doaj   +1 more source

Lipoleiomyoma With Bizarre Nuclei and Abundant Mast Cells [PDF]

, 2023
Rana K Alrasheed, Mohammed Abdelatif M Elhassan, Muradi A Murad   +2 more
openalex   +1 more source

Spatial Transcriptomics of TMJ Reveals a Remodeling Fibroblast‐Immune Microenvironment Driving Arthritis Pain

Advanced Science, EarlyView.
Spatial transcriptomics reveals a remodeled fibroblast‐immune microenvironment in the temporomandibular joint (TMJ) during arthritis. By combining seqFISH with genetic mouse models, this study uncovers TMJ spatial cell atalas, macrophage‐fibroblast crosstalk, and cytokine signaling pathways driving TMJ inflammation and pain.
Ziying Lin, Supawadee Jariyasakulroj, Yang Shu, Jingyi Chen, Qing Chang, Pao‐Fen Ko, Yuyueyang Qiu, Feixiang Chen, David Ahn, Zhen Zhao, Jian‐Fu Chen   +10 more
wiley   +1 more source

Safety of COVID‐19 vaccination in children with prior allergic reactions or mast cell disorders [PDF]

, 2023
Rishabh Kulkarni, Annabelle Arnold, Adrian Buzynski, Michaela Lucas   +3 more
openalex   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

Intratumoral Fusobacterium nucleatum Drives Cancer‐Associated Fibroblasts Enrichment and Immune Exclusion in Esophageal Squamous Cell Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
Fusobacterium nucleatum contributes to the progression of ESCC by inducing NF‐κB–mediated inflammatory signaling in tumor cells and promoting CAFs activation. Its presence may facilitate immune exclusion and tumor invasion through stromal remodeling. Furthermore, F.
Takashi Ofuchi, Qingjiang Hu, Kazuki Omachi, Kosuke Kanemitsu, Hajime Otsu, Yusuke Yonemura, Taro Tobo, Yoshifumi Baba, Masaaki Iwatsuki, Koshi Mimori   +9 more
wiley   +1 more source

Glucagon and insulin immunopositivity of mast cells in porcine gallbladder

Bulgarian Journal of Veterinary Medicine
It is well known that mast cells produce and release biologically active substances such as histamine, heparin, proteases, leukotrienes, cytokines, chemokines and growth factors. According to the avail-able scientific literature on that topic this is the
I. Stefanov, S. Stefanov, M. Gulubova
doaj   +1 more source

Neoadjuvant chemotherapy induces phenotypic mast cell changes in high grade serous ovarian cancer

Journal of Ovarian Research
Background High grade serous ovarian cancer (HGSOC) is the most lethal gynecologic malignancy in which patients have still yet to respond meaningfully to clinically available immunotherapies. Hence, novel immune targets are urgently needed. Our past work
Julia McAdams, Jasmine Ebott, Corinne Jansen, Chloe Kim, Daniela Maiz, Joyce Ou, Linda C. Hanley, Payton De La Cruz, Nicole E. James   +8 more
doaj   +1 more source

Mast cell disease [PDF]

Postgraduate Medical Journal, 1967
T I, McBride, G A, McDonald, W P, Duguid
openaire   +2 more sources

A Solution for Exosome‐Based Analysis: Surface‐Enhanced Raman Spectroscopy and Artificial Intelligence

Advanced Intelligent Discovery, EarlyView.
Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz, Zakarya Al‐Shaebi, Omer Aydin   +2 more
wiley   +1 more source