Results 201 to 210 of about 294,471 (310)

Simulating the year to minute wind spectrum with mesoscale‐coupled large‐eddy simulations

Quarterly Journal of the Royal Meteorological Society, EarlyView.
We coupled a large‐eddy simulation (resolution 50 m) to a mesoscale model (resolution 2 km), which takes boundary conditions from the ERA5 reanalysis. When using a large enough mesoscale domain (𝒪(1000 km)), the simulation setup can reproduce the observed temporal wind spectrum reasonably at all scales between one year and one minute. Furthermore, such
Bernard Postema, Chiel C. van Heerwaarden, Bart J.H. van Stratum, Pim van Dorp, Peter Baas, Harm J.J. Jonker   +5 more
wiley   +1 more source

Granzyme B from mast cells contributes to choroidal neovascularization in a model of wet age-related macular degeneration. [PDF]

Front Immunol
Uppal M, Hosseini A, Bilal K, Tan N, Ai Z, Khan W, Samad I, Gill G, Yoo HS, Chakravarthy H, Kuo CH, Xi J, Granville DJ, Matsubara JA.   +13 more
europepmc   +1 more source

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

Respirology, EarlyView.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

Sirt6 deficiency in mast cells promotes adipose fibroinflammation in obesity through galectin-3 signaling. [PDF]

Nat Commun
Song MY, Jeon YG, Do Yang J, Moon YJ, Kim JB, Bae EJ, Park BH.   +6 more
europepmc   +1 more source

Strategies for Assessing Post‐Wildfire Geomorphic Resilience in Semiarid Rivers

River Research and Applications, EarlyView.
ABSTRACT We review and summarize diverse components of a catchment that can be monitored after wildfire to assess the geomorphic resilience of the river corridor in semiarid regions. We distinguish upland portions of river catchments from river corridors.
Ellen Wohl, Shayla Triantafillou, Alex Thornton‐Dunwoody, Connor Mertz, Katie Larkin, William Keenan, Steven Griffin, Dylan Davis, Lindsey Blehm   +8 more
wiley   +1 more source

Cell adhesion molecule 1 is upregulated in connective tissue mast cells and potentially contributes in IgE-mediated degranulation. [PDF]

Sci Rep
Hagiyama M, Yoneshige A, Takeuchi F, Inoue T, Ito A.   +4 more
europepmc   +1 more source

Shape‐Memory Collagen/Silk‐Fibroin Scaffold for Dura Sealing and Skull Base Regeneration

Small, EarlyView.
ABSTRACT When a skull base defect occurs, reconstruction is typically performed using a variety of autologous grafts, flaps, or synthetic materials. Failure to achieve appropriate management and closure can lead to serious consequences, such as cerebrospinal fluid (CSF) leakage and subsequent meningitis.
SooJung Chae, Donghyeok Kim, Dongyun Kim, JaeYoon Lee, Sang Duk Hong, GeunHyung Kim   +5 more
wiley   +1 more source

Introduction of Mature Mast Cells into Bone Marrow Alters Bone Metabolism in Growing Mice. [PDF]

Int J Mol Sci
Wong CP, Keune JA, Philbrick KA, Branscum AJ, Iwaniec UT, Turner RT.   +5 more
europepmc   +1 more source

A Cross‐Organ Symphony of Human Immune System Maturation

Organ Medicine, EarlyView.
Zhan‐Li Chen
wiley   +1 more source

Identification of genetically predicted protein biomarkers and drug targets for prostate cancer via Mendelian randomization

VIEW, EarlyView.
Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai, Tianming Peng, Zhiyue Xie, Chuqian Zhen, Chen Yao, Nan Peng, Qianyi Li, Yuzhong Yu, Jiming Bao, Xian‐Lu Song, Mingkun Chen, Shan‐Chao Zhao   +11 more
wiley   +1 more source