Results 201 to 210 of about 147,604 (268)

Choroidal Mast Cells and Their Degranulation Are a Pivotal Trigger for Myopia Development. [PDF]

Invest Ophthalmol Vis Sci
Shi J, Ikeda SI, Fukuchi T, Chen J, Gettinger K, Imanishi S, Negishi K, Tsubota K, Kurihara T.   +8 more
europepmc   +1 more source

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, EarlyView.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh, Lior Seluk, Philipp Bosch, Carolina Aguiar, Jens Thiel, Bernhard Hellmich, Michael E. Wechsler, Salman Siddiqui   +7 more
wiley   +1 more source

Introduction of Mature Mast Cells into Bone Marrow Alters Bone Metabolism in Growing Mice. [PDF]

Int J Mol Sci
Wong CP, Keune JA, Philbrick KA, Branscum AJ, Iwaniec UT, Turner RT.   +5 more
europepmc   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Cell adhesion molecule 1 is upregulated in connective tissue mast cells and potentially contributes in IgE-mediated degranulation. [PDF]

Sci Rep
Hagiyama M, Yoneshige A, Takeuchi F, Inoue T, Ito A.   +4 more
europepmc   +1 more source

Novel Bispecific Engagers Targeting the CεmX Domain of mIgE‐Expressing Cells

Allergy, EarlyView.
We developed bispecific TCE & NKCE targeting the CεmX domain of mIgE to eliminate IgE‐producing cells. Both constructs demonstrated potent, specific, dose‐dependent cytotoxicity and selective immune activation in vitro. These results highlight their promise as off‐the‐shelf, potentially curative therapeutics for IgE‐associated allergic diseases ...
Constantin Möller, Julia Hambach, Alessa Zoe Schaffrath, Thomas Eden, Sophia Cichutek, Anna Josephine Gebhardt, Natalie Tode, Ronald Maitschke‐Rajasekharan, Philipp Lewe, Sharon Qi, Susanne Witt, Marie Eggers, Nicola M. Tomas, Friedrich Haag, Friedrich Koch‐Nolte, Boris Fehse, Kristoffer Riecken   +16 more
wiley   +1 more source

Interactions Between Tryptase-Positive Mast Cells and Melanin-A⁺ Cells in the Microenvironment of Cutaneous Melanoma. [PDF]

Int J Mol Sci
Atiakshin D, Demyashkin G, Silakov K, Prikhodko A, Shchekin V, Alekhnovich A, Grivtsova L, Davydov D, Klabukov I, Baranovskii D, Ivanov S, Elieh-Ali-Komi D, Buchwalow I, Tiemann M, Kostin A, Shegay P, Kaprin A.   +16 more
europepmc   +1 more source

Mast Cells Are Not Essential for Pubertal Mammary Gland Branching. [PDF]

Eur J Immunol
Kapoor S, Munz CM, Marsden J, Carvalho C, Tinsley H, Pinto MM, Malengier-Devlies B, Becker S, Seuzaret G, Patatsos K, Akyol R, Pederson AB, Wilson G, Dalod M, Gentek R.   +14 more
europepmc   +1 more source

Dendrimeric Antigens for Passive Mast Cell Activation in the Evaluation of Amoxicillin Allergy

Allergy, EarlyView.
DeAns with defined nanoscale structure reveal that conjugate size and determinant density govern IgE‐mediated effector‐cell activation in AX allergy. All DeAn generations bind to sIgE in inhibition immunoassay, but only larger DeAns trigger FcεRI‐dependent responses in mouse MC, huRBL‐2H3, and LUVA cells.
Amene Tesfaye Ayane, Maria Salas, Sara Benede, Maria J. Rodriguez‐Sanchez, Maria J. Rodriguez‐Sojo, Isabel M. Jiménez‐Sánchez, Gador Bogas, Ezequiel Perez‐Inestrosa, Cristobalina Mayorga, Juan L. Paris, Alba Rodríguez‐Nogales, María J. Torres, María I. Montañez   +12 more
wiley   +1 more source