Results 91 to 100 of about 77,151 (268)

Implementing PEN‐FAST for penicillin allergy delabeling in a high‐prevalence population

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 1, Page 57-63, January 2026.
Summary Background and objectives Self‐reported penicillin allergies lead to the use of broad‐spectrum antibiotics, increase drug resistance, and constitute an economic burden. The PEN‐FAST score aims to identify low‐risk patients for direct drug provocation tests (DPT) without prior skin testing with a reported negative predictive value (NPV) of over ...
Deniz Göcebe, Katharina S. Kommoss, Martin Hartmann, Alexander H. Enk, Knut Schäkel   +4 more
wiley   +1 more source

Preclinical human models and emerging therapeutics for advanced systemic mastocytosis

Haematologica, 2018
Mastocytosis is a term used to denote a group of rare diseases characterized by an abnormal accumulation of neoplastic mast cells in various tissues and organs.
Michel Arock, Ghaith Wedeh, Gregor Hoermann, Siham Bibi, Cem Akin, Barbara Peter, Karoline V. Gleixner, Karin Hartmann, Joseph H. Butterfield, Dean D. Metcalfe, Peter Valent   +10 more
doaj   +1 more source

Expanding the Immunologic and Neuronal Landscape of IgE‐Mediated Anaphylaxis

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Anaphylaxis is a life‐threatening immunoglobulin E (IgE)‐mediated type I hypersensitivity reaction with rising prevalence and burden. It involves mast cell degranulation upon cross‐linking of antigen on mast cell‐bound IgE. Mechanisms of IgE‐mediated anaphylaxis remain incompletely understood, particularly the induction of systemic symptoms ...
Ruchi Biswas, Jamie Moore Fried, Maria A. Curotto de Lafaille   +2 more
wiley   +1 more source

Targeting phosphatidylinositol-3-kinase pathway for the treatment of Philadelphia-negative myeloproliferative neoplasms [PDF]

, 2015
Myeloproliferative neoplasms (MPN) are a diverse group of chronic hematological disorders that involve unregulated clonal proliferation of white blood cells.
Kapur, Reuben, Pandey, Ruchi
core   +1 more source

Relapse of Acute Myeloid Leukemia With Concomitant Systemic Mastocytosis Five Years Post Allogenic Hematopoietic Stem Cell Transplantation

Case Reports in Hematology, Volume 2026, Issue 1, 2026.
Systemic mastocytosis (SM) with associated hematological neoplasia (SM‐AHN) is a rare and aggressive condition characterized by abnormal clonal proliferation of mast cells and the concurrent occurrence of hematologic malignancies, such as acute myeloid leukemia (AML).
Sona Vardanyan, Hilde K. Gjelberg, Lars Helgeland, Galina Tsykunova, Rakel Brendsdal Forthun, Håkon Reikvam, Stephen E. Langabeer   +6 more
wiley   +1 more source

Systemic Mastocytosis - a Diagnostic Challenge [PDF]

, 2014
Mastocytosis refers to a group of disorders characterized by the infiltration of clonally derived mast cells to the skin or extracutaneous tissues resulting in a heterogeneous clinical picture. It is a rare hematologic disorder in all its forms.
Galzerano, A, Lladó, AC, Mihon, C, Silva, M   +3 more
core  

Tissue‐Resident Myeloid and Histiocytic Cells in Health and Disease: Novel Emerging Concepts

American Journal of Hematology, Volume 100, Issue 12, Page 2305-2319, December 2025.
ABSTRACT Although all myeloid cells are considered to derive from hematopoietic stem cells, the cells in each myeloid lineage are heterogeneous populations, and their distribution and functions vary, depending on underlying physiologic and pathologic processes, age, sex, and genetic and epigenetic signatures.
Peter Valent, Johann Wojta, Petri T. Kovanen, Olivier Hermine, Falko Fend, Karl Sotlar, Hildegard Greinix, Klaus Geissler, Karin Hartmann, Juliana Schwaab, Marco Herling, Laura Boccuni, Lukas Kazianka, Max Vincent John, Wolfgang R. Sperr, Carina Zierfuss, Alexandar Tzankov, Christian Sillaber, Milen Minkov, Gregor Hoermann, Matthew Collin, Hans‐Peter Horny, Torsten Haferlach, Maria Sibilia, Julien Haroche, Paul La Rosée, Alberto Orfao, Michel Arock   +27 more
wiley   +1 more source

Atypical chronic myeloid leukemia: From diagnosis to molecular features and therapeutic options

HemaSphere, Volume 9, Issue 12, December 2025.
ABSTRACT Atypical chronic myeloid leukemia (aCML) is a rare form of myelodysplastic (MDS)/myeloproliferative neoplasm (MPN) overlap disorder characterized by neutrophilic leukocytosis with circulating immature myeloid cells (IMC), frequent hepatosplenomegaly, and poor prognosis with high rates of leukemic transformation.
Alessandra Iurlo, Daniele Cattaneo, Umberto Gianelli, Francesco Passamonti   +3 more
wiley   +1 more source

Mast cell-related disorders presenting with Kounis syndrome [PDF]

, 2016
Letter to the Editor.-- et al.Peer ...
Escribano, Luis, García-Montero, Andrés, Gonzalez-de-Olano, David, Jara-Acevedo, Maria, Matito, Almudena, Morgado, J. M., Orfao, Alberto, Sánchez-Muñoz, Laura, Teodosio, Cristina, Álvarez-Twose, Iván   +9 more
core   +1 more source

Pediatric Mastocytosis

Journal of Investigative Dermatology, 1991
The onset of mastocytosis occurs between birth and 2 years of age in approximately 55% of all cases; an additional 10% develop the disease before the age of 15 years. Mastocytosis in these age groups differs in many respects from mastocytosis that has its onset in adulthood. The typical presentation of pediatric-onset mastocytosis consists of cutaneous
Kettelhut, Brett V., Metcalfe, Dean D.
openaire   +4 more sources