Results 81 to 90 of about 74,252 (184)

Preclinical human models and emerging therapeutics for advanced systemic mastocytosis

Haematologica, 2018
Mastocytosis is a term used to denote a group of rare diseases characterized by an abnormal accumulation of neoplastic mast cells in various tissues and organs.
Michel Arock, Ghaith Wedeh, Gregor Hoermann, Siham Bibi, Cem Akin, Barbara Peter, Karoline V. Gleixner, Karin Hartmann, Joseph H. Butterfield, Dean D. Metcalfe, Peter Valent   +10 more
doaj   +1 more source

Targeting phosphatidylinositol-3-kinase pathway for the treatment of Philadelphia-negative myeloproliferative neoplasms [PDF]

, 2015
Myeloproliferative neoplasms (MPN) are a diverse group of chronic hematological disorders that involve unregulated clonal proliferation of white blood cells.
Kapur, Reuben, Pandey, Ruchi
core   +1 more source

Circulating Tumour DNA and Extracellular Vesicle‐Associated DNA as Biomarkers for Cancer Detection: A Systematic Review and Meta‐Analysis

Journal of Extracellular Biology, Volume 5, Issue 4, April 2026.
ABSTRACT Liquid biopsy is an emerging tool that allows the detection and monitoring of tumours through the analysis of various analytes in biofluids like blood. An important component of liquid biopsy is circulating tumour (ct) DNA, small fragments of DNA that are released by cancer cells, which have been shown to be a robust biomarker and are already ...
Tad Wu, Kyle Dickinson, Ian Schiller, Thupten Tsering, Yunxi Chen, Amélie Nadeau, Nandini Dendukuri, Venkata Ramana Agnihotram, Julia V. Burnier   +8 more
wiley   +1 more source

Cutaneous mastocytosis: Two pediatric cases treated with topical pimecrolimus. [PDF]

, 2010
Cutaneous mastocytosis is characterized by increased numbers of skin mast cells that release mediators causing pruritus, urticaria, and flushing. Most pediatric mastocytosis patients exhibit the pattern of urticaria pigmentosa, which typically appears ...
Azevedo, R, Correia, O, Delgado, L, Duarte, AF, Quirino, P   +4 more
core   +1 more source

Receptor tyrosine kinase and p16/CDKN2 expression in a case of tripe palms associated with non-small-cell lung cancer [PDF]

, 1999
Background: Tripe palms is a descriptive term for a cutaneous paraneoplastic keratoderma. Tripe palms are frequently associated with gastric and pulmonary carcinoma. The pathogenetic mechanism remains unknown.
Bezold, G., Dieterle, C., Greulich, K. M., Krähn, Gertraud, Peter, R. U., Wolff, H.   +5 more
core   +1 more source

Nodular mastocytosis: a case study

Vestnik Dermatologii i Venerologii, 2017
A case study of nodular mastocytosis is described. Tacrolimus was used to treat skin manifestations of mastocytosis.
E. V. Pavlova, I. V. Ulitina, YU. E. Rusak, E. N. Efanova, E. N. Ivannikova   +4 more
doaj   +1 more source

Enhanced PIEZO1 expression in mast cells of mastocytosis skin lesions: Relevance to Darier's sign

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Yoshiaki Kobayashi, Nobuhiro Nakano, Nguyen Quoc Vuong Tran, Yuki Nakamura, Lisa Minai, Takashi Okamoto, Daiki Nakagomi, Tatsuki R. Kataoka, Tatsuyoshi Kawamura, Atsuhito Nakao   +9 more
wiley   +1 more source

Trüptaasi füsioloogiline ja kliiniline tähendus [PDF]

, 2006
Trüptaas on oluline mediaator, mis vabaneb nuumrakkude aktivatsioonil põletikuliste ja allergiliste reaktsioonide korral. Trüptaasi sisalduse suurenemine esineb 1–6 tundi pärast süsteemset anafülaktilist reaktsiooni, mis võimaldab kasutada trüptaasi ...
Velbri, Sirje
core   +2 more sources

Schwann Cell TRPA1, a Proalgesic Ion Channel, Mediates Neuroinflammation and Fibromyalgia‐Associated Behaviours in Mice

Journal of Neurochemistry, Volume 170, Issue 4, April 2026.
Cellular and molecular mechanisms contributing to TRPA1‐mediated mechanical and cold hypersensitivity and peripheral neuroinflammation in the reserpine‐induced experimental fibromyalgia model. (1) Macrophage‐originated reactive oxygen species (ROS; purple dots) target the transient receptor potential ankyrin 1 (TRPA1) channel localised in Schwann cells.
Evelyne Silva Brum, Maria Fernanda Pessano Fialho, Daniel Souza Monteiro de Araújo, Lorenzo Landini, Matilde Marini, Francesco De Logu, Romina Nassini, Sara Marchesan Oliveira   +7 more
wiley   +1 more source

Mast cell-related disorders presenting with Kounis syndrome [PDF]

, 2016
Letter to the Editor.-- et al.Peer ...
Escribano, Luis, García-Montero, Andrés, Gonzalez-de-Olano, David, Jara-Acevedo, Maria, Matito, Almudena, Morgado, J. M., Orfao, Alberto, Sánchez-Muñoz, Laura, Teodosio, Cristina, Álvarez-Twose, Iván   +9 more
core   +1 more source