Results 101 to 110 of about 81,928 (305)

Diagnosis, management and the burden of symptoms of mastocytosis from the physician's perspective: A nationwide study

British Journal of Haematology, EarlyView.
Summary Mastocytosis is categorized into cutaneous mastocytosis (CM), mast cell sarcoma and systemic mastocytosis (SM). Within SM, indolent SM (ISM) is the more frequent subtype. Adult patients with CM but without an extracutaneous biopsy are classified as having mastocytosis in the skin (MIS), a provisional diagnosis.
Julien Rossignol, Laurence Bouillet, Cristina Bulai‐Livideanu, Stéphane Barete, Julie Bruneau, Clément Gourguechon, Laura Polivka, Angèle Soria, Olivier Lortholary, Trevor Stanbury, Benoit Bouquillon, Cedric Sauvage, Rose Marie Javier, Olivier Hermine, Michel Arock, the CEREMAST Network   +15 more
wiley   +1 more source

Depression in patients with mastocytosis: prevalence, features and effects of masitinib therapy. [PDF]

PLoS ONE, 2011
Depression in patients with mastocytosis is often reported but its prevalence and characteristics are not precisely described. In addition, the impact of therapies targeting mast cells proliferation, differentiation and degranulation on psychic symptoms ...
Daniela Silva Moura, Serge Sultan, Sophie Georgin-Lavialle, Nathalie Pillet, François Montestruc, Paul Gineste, Stéphane Barete, Gandhi Damaj, Alain Moussy, Olivier Lortholary, Olivier Hermine   +10 more
doaj   +1 more source

Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway [PDF]

, 2018
Mutations in KIT and TET2 are associated with myeloid malignancies. We show that loss of TET2-induced PI3K activation and -increased proliferation is rescued by targeting the p110α/δ subunits of PI3K.
Gerbaulet, A, Janga, SC, Kapur, R, Mali, RS, Paczesny, S, Palam, LR, Ramdas, B, Roers, A, Srivatsan, SN, Takemoto, CM, Tiu, RV, Vanhaesebroeck, B, Visconte, V, Xu, M   +13 more
core   +1 more source

New Insights into the Pathogenesis of Systemic Mastocytosis

International Journal of Molecular Sciences, 2021
Mastocytosis is a type of myeloid neoplasm characterized by the clonal, neoplastic proliferation of morphologically and immunophenotypically abnormal mast cells that infiltrate one or more organ systems.
Zhixiong Li
semanticscholar   +1 more source

Assessment of Patients With Beta‐Lactams Positive Provocation Tests by Biomarkers of IgG‐Related Neutrophil Activation

Clinical &Experimental Allergy, EarlyView.
Neutrophil activation in beta‐lactams (BL) immediate hypersensitivity reactions (IHR). Factor component analysis of IHR biomarkers suggests an IgG‐mediated mechanism. We propose Neutrophil Elastase as a biomarker of neutrophil activation in BL IHR. ABSTRACT Background Beta‐lactams (BLs) are the predominant cause of immediate allergic reactions to drugs.
Adrienne Astrid Gallizzi, Rosa‐Maria Guéant‐Rodriguez, Cosmin Boteanu, Jean‐Marc Alberto, Cécile Lakomy, Huguette Louis, Celine Chery, Pauline Renard, Véronique Regnault, Ramia Safar, Almut Heinken, Antonino Romano, Jose‐Julio Laguna, Jean‐Louis Guéant   +13 more
wiley   +1 more source

Clinical features of mastocytosis at pediatric patients

Vestnik Dermatologii i Venerologii, 2017
Mastocytosis is relevant to heterogeneous disease group characterized with redundant accumulation and proliferation of mast cells in tissues. The skin form of mastocytosis is mainly occurs in children.
D. V. Proshutinskaya, O. S. Makoveckaya
doaj   +1 more source

Metastases risk in thin cutaneous melanoma: Prognostic value of clinical-pathologic characteristics and mutation profile [PDF]

, 2018
Background: A high percentage of patients with thin melanoma (TM), defined as lesions with Breslow thickness ≤1 mm, presents excellent long-term survival, however, some patients develop metastases.
Calvieri, Stefano, Carbone, Anna, Donati, Pietro, Frascione, Pasquale, MARRAFFA, FEDERICA, Mattia, Cinzia Di, Ottini, Laura, Paolino, Giovanni, Richetta, Antonio G., Rizzolo, Piera, Silvestri, Valentina, Valentini, Virginia, Zelli, Veronica   +12 more
core   +1 more source

Protease profile of normal and neoplastic mast cells in the human bone marrow with special emphasis on systemic mastocytosis

Histochemistry and Cell Biology, 2021
Mast cells (MC) are immune cells that produce a variety of mediators, such as proteases, that are important in the body’s immune responses. MC proteases have pronounced multifunctionality and in many respects determine the biological characteristics of ...
D. Atiakshin, I. Buchwalow, P. Horny, M. Tiemann   +3 more
semanticscholar   +1 more source

Implementing PEN‐FAST for penicillin allergy delabeling in a high‐prevalence population

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Self‐reported penicillin allergies lead to the use of broad‐spectrum antibiotics, increase drug resistance, and constitute an economic burden. The PEN‐FAST score aims to identify low‐risk patients for direct drug provocation tests (DPT) without prior skin testing with a reported negative predictive value (NPV) of over ...
Deniz Göcebe, Katharina S. Kommoss, Martin Hartmann, Alexander H. Enk, Knut Schäkel   +4 more
wiley   +1 more source

Kounis Syndrome Associated With Selective Anaphylaxis to Cefazolin. [PDF]

, 2018
info:eu-repo/semantics ...
Chambel, M, Correia, M, Gaspar, A, Morais-Almeida, M, Mota, I, Sequeira, T   +5 more
core   +1 more source