Results 51 to 60 of about 449,069 (245)

Spectral-fluctuations test of the quark-model baryon spectrum [PDF]

open access: yesPhys.Rev.Lett.98:062001,2007, 2007
We study the low-lying baryon spectrum (up to 2.2 GeV) provided by experiments and different quark models using statistical tools which allow to postulate the existence of missing levels in spectra. We confirm that the experimental spectrum is compatible with Random Matrix Theory --the paradigmatic model of quantum chaos--, and we find that the quark ...
arxiv   +1 more source

Contribution of Dravyaguna to Herbal Materia Medica [PDF]

open access: yes, 2008
Dravyaguna is essentially compilation of ancient Indian medical knowledge. Dravyaguna has made significant contribution to the Herbal Materia Medica. The term ‘Herbal Materia Medica’ covers global medicinal plants and is not restricted to one or other ...
Singh, Amritpal
core   +1 more source

Meisoindigo Acts as a Molecular Glue to Target PKMYT1 for Degradation in Chronic Myeloid Leukemia Therapy

open access: yesAdvanced Science, EarlyView.
Meisoindigo targets PKMYT1 for degradation by acting as a molecular glue that enhances PKMYT1‐TRIM25 interaction, leading to K48‐linked ubiquitination and subsequent proteasomal degradation, thereby exerting therapeutic effects in chronic myeloid leukemia.
Zhao‐Xin Zhang   +10 more
wiley   +1 more source

Dezocine Exerts Analgesic Effects in Chronic Pain by Activation of κ- and μ-Opioid Receptors and Inhibition of Norepinephrine and Serotonin Reuptake

open access: yesPain Research and Management
Conclusion: These results suggest that, in neuropathic pain, the analgesic effects of dezocine are mediated through KOR and MOR activation, together with norepinephrine reuptake inhibition (NRI) and serotonin reuptake inhibition.
Zihan Liu   +7 more
doaj   +1 more source

Deciphering the Metabolic Impact and Clinical Relevance of N‐Glycosylation in Colorectal Cancer through Comprehensive Glycoproteomic Profiling

open access: yesAdvanced Science, EarlyView.
The comprehensive proteomic and N‐glycoproteomic analyses of 45 colorectal cancer tissues with matched normal adjacent tissues identified 7125 intact N‐glycopeptides from 704 glycoproteins. A glycosylation site‐protein function network revealing metabolic dysregulation is constructed and a model differentiating tumors from normal tissues is developed ...
Guobin Liu   +10 more
wiley   +1 more source

Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species

open access: yesAdvanced Science, EarlyView.
This study identifies ferroptosis as a key driver of cellular senescence, with its inhibition delaying aging and extending healthspan across species. During senescence, ferroptosis worsens, increasing oxidative stress and lipid peroxidation, which accelerate aging.
Hai‐Jun Fu   +15 more
wiley   +1 more source

Maltese medical Pauline traditions [PDF]

open access: yes, 2010
The advent of the apostle Paul and evangelist Luke to the Maltese Islands in 60 AD led to the development of a number of pseudo-historic and medical beliefs that apparently saw their rise around the 12th century and reached a climax during the 17-18th ...
Savona-Ventura, Charles
core  

Dual‐Locking the SARS‐CoV‐2 Spike Trimer: An Amphipathic Molecular “Bolt” Stabilizes Conserved Druggable Interfaces for Coronavirus Inhibition

open access: yesAdvanced Science, EarlyView.
A new amphipathic molecule, S416 is discovered, that locks the SARS‐CoV‐2 spike protein in its closed state, blocking viral entry. S416 acts as a molecular bolt, binding six sites: three between adjacent RBDs and three connecting NTDs to RBDs. This dual‐locking mechanism stiffens the spike structure and reduces its flexibility.
Shiliang Li   +21 more
wiley   +1 more source

Application of barcode high-resolution melting for rapid authentication of the medicinal plant Psammosilene tunicoides

open access: yesBiotechnology & Biotechnological Equipment, 2016
Psammosilene tunicoides is an important herb used in traditional Chinese medicine. It has been proved to benefit the stomach and treat rheumatism and gout.
Jingjian Li   +4 more
doaj   +1 more source

Hepatoprotective effects of Cassiae Semen on mice with non-alcoholic fatty liver disease based on gut microbiota

open access: yesCommunications Biology, 2021
Luo, Wu, et al. assess the ability of Cassiae Semen and its extracted components to alleviate non-alcoholic fatty liver disease (NAFLD) in mice.
Hanyan Luo   +9 more
doaj   +1 more source

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