Results 81 to 90 of about 2,019,496 (342)
Constructing a concept of number [PDF]
, 2018 Numbers are concepts whose content, structure, and organization are influenced by the material forms used to represent and manipulate them. Indeed, as argued here, it is the inclusion of multiple forms (distributed objects, fingers, single- and two ...
Overmann, Karenleigh
core +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
, 2017 In this work, we aim to study the thermal properties of materials using classical molecular dynamics simulations and specialized numerical methods. We focus primarily on the thermal conductivity \kappa using non-equilibrium molecular dynamics to study ...
Jund, Philippe, Severin, Jonathan
core +2 more sources
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Finite element modelling of cold formed stainless steel columns [PDF]
, 2004 This paper describes the results obtained from a finite element investigation into the load capacity of column members of lipped channel cross-section, cold formed from Type 304 stainless steel, subjected to concentric and eccentric compression loading ...
Macdonald, M., Rhodes, J.
core +3 more sources
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Numerical and experimental investigation of yielding for cohesive dry powder [PDF]
, 2015 We study the effect of particle cohesion on the steady state shear strength of a granular material. For cohesive powders, the steady state shear loci (termination loci) from DEM simulations are nonlinear with a peculiar pressure dependence due to the non-
Luding, S. +3 more
core +1 more source
A non‐linear interface element for 3D mesoscale analysis of brick‐masonry structures
, 2011 This paper presents a novel interface element for the geometric and material non‐linear analysis of unreinforced brick‐masonry structures. In the proposed modelling approach, the blocks are modelled using 3D continuum solid elements, whereas the mortar ...
L. Macorini, B. Izzuddin
semanticscholar +1 more source