Results 41 to 50 of about 519,396 (299)

Analysis of Tool Utilization from Material Removal Rate Perspective

Procedia CIRP, 2015
An end of life strategy algorithm has been used to study a CNC program to evaluate how the cutting inserts are used in terms of their full utilization. Utilized tool life (UTL) and remaining tool life (RTL) were used to evaluate if the insert has been used to its limits of expected tool life, or contributing to an accumulated tool waste.
Hernández, A.E. Bonilla, Beno, Tomas, Repo, Jari, Wretland, Anders   +3 more
openaire   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Calculations of material removal, removal rate, and Preston coefficient in continuous lapping/polishing machines [PDF]

Precision Engineering, 1993
Lapping and polishing machines usually do not have deterministic model to pre-determine removal rate and total material to be removed. The removal process is mainly affected by relative motion between the lap and the substrates, by load applied, and by mechano-chemical characteristics of the substrate material, as well as the abrasive and lap materials.
openaire   +3 more sources

Electrochemical micromachining of galvanized iron sheets: process optimization and performance evaluation

Journal of Electrochemical Science and Engineering
Electrochemical micromachining (ECMM) is a promising non-traditional technique for fabricating micro-features on conductive materials with high precision and minimal thermal effects.
Nadanasabapathi Sivashankar, Kadhiresan Santhanam, Shikandar Prasad, Mamidala Jawahar, Rajasekaran Thanigaivelan   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Experimental investigation and optimization of wall deflection and material removal rate in milling thin-wall parts

Manufacturing Review, 2021
The selection of optimal process parameters is essential while machining thin-wall parts since it influences the quality of the product and affects productivity.
Bolar Gururaj, Joshi Shrikrishna Nandkishor   +1 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Parameters Optimization for Electropolishing Titanium by Using Taguchi-Based Pareto ANOVA

Metals, 2023
Material removal rate in electropolishing is often overlooked because this process generally addressed for surface finish; however, it is paramount on metallic sheet machining possessed with intricate geometry.
Gunawan Setia Prihandana, Tutik Sriani, Mohd Fadzil Jamaludin, Farazila Yusof, Budi Arifvianto, Muslim Mahardika   +5 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source