Results 41 to 50 of about 510,222 (299)

Analysis of Tool Utilization from Material Removal Rate Perspective

Procedia CIRP, 2015
An end of life strategy algorithm has been used to study a CNC program to evaluate how the cutting inserts are used in terms of their full utilization. Utilized tool life (UTL) and remaining tool life (RTL) were used to evaluate if the insert has been used to its limits of expected tool life, or contributing to an accumulated tool waste.
Hernández, A.E. Bonilla, Beno, Tomas, Repo, Jari, Wretland, Anders   +3 more
openaire   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Electrochemical micromachining of galvanized iron sheets: process optimization and performance evaluation

Journal of Electrochemical Science and Engineering
Electrochemical micromachining (ECMM) is a promising non-traditional technique for fabricating micro-features on conductive materials with high precision and minimal thermal effects.
Nadanasabapathi Sivashankar, Kadhiresan Santhanam, Shikandar Prasad, Mamidala Jawahar, Rajasekaran Thanigaivelan   +4 more
doaj   +1 more source

Electrolytically Ionized Abrasive-Free CMP (EAF-CMP) for Copper

Applied Sciences, 2021
Chemical–mechanical polishing (CMP) is a planarization process that utilizes chemical reactions and mechanical material removal using abrasive particles.
Seonghyun Park, Hyunseop Lee
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Calculations of material removal, removal rate, and Preston coefficient in continuous lapping/polishing machines [PDF]

Precision Engineering, 1993
Lapping and polishing machines usually do not have deterministic model to pre-determine removal rate and total material to be removed. The removal process is mainly affected by relative motion between the lap and the substrates, by load applied, and by mechano-chemical characteristics of the substrate material, as well as the abrasive and lap materials.
openaire   +3 more sources

PERFORMANCE ANALYSIS OF EDM ON GREY CAST IRON USING RSM AND TOPSIS METHOD

Applied Engineering Letters, 2023
Electro discharge machining (EDM) process is applied to machine hard and difficult to cut materials. In this research hard material namely, grey cast iron is used as a workpiece and copper electrode 2 mm in diameter is used for making holes through EDM ...
P. Venugopal, K.G. Saravanan, R. Thanigaivelan   +2 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source