Results 61 to 70 of about 541,541 (258)

Optimization of processing parameters during electrical discharge diamond grindingof RB-SiC ceramics based on grey relational theory

Jin'gangshi yu moliao moju gongcheng, 2021
The electrical discharge diamond grinding tests of RB-SiC ceramics were performed. The influence of wheel parameters, grinding parameters and discharge parameters on surface roughness, material removal rate, wheel wear rate and normal grinding force were
HUANG Shuqiang, WEI Zongze, RAO Xiaoshuang, LI Chen, ZHANG Feihu   +4 more
doaj  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Machine Learning-Based Prediction of EDM Material Removal Rate and Surface Roughness

Journal of Manufacturing and Materials Processing
Examining the electrical discharge machining (EDM) process is challenging in manufacturing technology due to the complexity of the physical events that take place in the gaps between electrodes.
Isam Qasem, Amjad Alsakarneh
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Analysis on mechanism of material removal rate and surface flow machining process [PDF]

MATEC Web of Conferences
A novel finishing technique called abrasive flow machining (AFM) uses abrasive particles as the instrument for material removal. The term "self-deformable stone" refers to the abrasive particle-containing carrier medium, and AFM is commonly known as "no ...
Kondala Rao Peram, Ranga Janardhana G.
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Optimization of Process Parameters in Electropolishing of SS 316L Utilizing Taguchi Robust Design

Journal of Manufacturing and Materials Processing
In electropolishing, the material removal rate is frequently neglected, as this process is primarily focused on surface finish, and yet, it is crucial for manufacturing metallic sheets.
Muhammad Kemal Syahputra, Kartika Nur ‘Anisa’, Rizky Astari Rahmania, Farazila Yusof, Pradeep Dixit, Muslim Mahardika, Gunawan Setia Prihandana   +6 more
doaj   +1 more source

Study on Material Removal Rate in EDM Of 9XC Steel

International Journal of Mechanical Engineering
The present work examines the effects of discharge current (𝐼𝑒) and ignition voltage (𝑈𝑧) on the rate of material removal (MRR, denoted as 𝑄) during EDM of 9XC alloy tool steel, a very high-hardness tool steel used for mould manufacturing. In this article, a 22 full factorial design was used to systematically study the effects of process variables on a
Vinh-Binh Bui, Xuan-Thao Dang, Hong-Son Nguyen, Nhu-Uyen Vo Thi   +3 more
openaire   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source