Results 81 to 90 of about 3,143,235 (349)

The analysis of material removal rate of WEDM miniature gears

Engineering review, 2021
Gear fabrication in wire electrical discharge machining (WEDM) plays an important role in manufacturing industries. This paper describes the analysis and optimization of process parameters for the fabrication of spur gear on brass spur gear on brass workpiece (10cmx15cmx6mm) material by wire EDM process.
Goyal, Ashish, Singh, Vyom, Patel, Abhishek   +2 more
openaire   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Electrolytically Ionized Abrasive-Free CMP (EAF-CMP) for Copper

Applied Sciences, 2021
Chemical–mechanical polishing (CMP) is a planarization process that utilizes chemical reactions and mechanical material removal using abrasive particles.
Seonghyun Park, Hyunseop Lee
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Influence of pulse repetition rate on morphology and material removal rate of ultrafast laser ablated metallic surfaces

Optics and lasers in engineering, 2019
Ultrafast laser ablation is an efficient method for precise micro-machining. Thanks to the recent development of high repetition rate ultrafast lasers, high speed laser scanning of surfaces is more and more employed to generate micro-/nano- surface ...
X. Sedao, M. Lenci, A. Rudenko, N. Faure, A. Pascale-Hamri, J. Colombier, C. Mauclair   +6 more
semanticscholar   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Machine Learning-Based Prediction of EDM Material Removal Rate and Surface Roughness

Journal of Manufacturing and Materials Processing
Examining the electrical discharge machining (EDM) process is challenging in manufacturing technology due to the complexity of the physical events that take place in the gaps between electrodes.
Isam Qasem, Amjad Alsakarneh
doaj   +1 more source

Estimation of material removal rate distribution in double-sided polishing of thick square workpiece considering workpiece attitude

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2019
A workpiece attitude during polishing process is known to affect material removal rate distribution, which is one of the most significant properties in polishing process.
Yohei HASHIMOTO, Tomoya SANO, Tatsuaki FURUMOTO, Akira HOSOKAWA   +3 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A progress report on the evaluation of metal cutting coolants [PDF]

, 1965
An intensive investigation into the grinding process was carried out in The College of Aeronautics Machine Tools Laboratory during 1955-6. The outcome of this work was a method of evaluating the efficiency of grinding wheel specifications.
Chater, T.
core