Results 101 to 110 of about 3,143,235 (349)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Laser balancing system for high material removal rates [PDF]

open access: yes
A laser technique to remove material in excess of 10 mg/sec from a spinning rotor is described. This material removal rate is 20 times greater than previously reported for a surface speed of 30 m/sec. Material removal enhancement was achieved by steering
Georgalas, G.   +2 more
core   +1 more source

A review on the rotary ultrasonic machining of advanced ceramics [PDF]

open access: yes, 2008
Advanced ceramics are likely candidates for many industrial applications due to their superior properties. However, their high machining costs lead to limited applications.
Hamzah, Esah, Khoo, C. Y., Sudin, Izman
core  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Prediction of surface roughness and material removal rate in wire electrical discharge machining on aluminum based alloys/composites using Taguchi coupled Grey Relational Analysis and Artificial Neural Networks

open access: yesApplications of Surface Science, 2019
In this research, a novel aluminum alloy and metal matrix composite was designed and developed for self healing purpose. Tin at varying weight percentages (5, 10, 15 & 20 wt%) was alloyed into aluminum along with other alloying elements to form a new set
T. Thankachan   +7 more
semanticscholar   +1 more source

Mechanics,Mechanisms and Modeling of the Chemical Mechanical Polishing Process [PDF]

open access: yes, 2002
The Chemical Mechanical polishing (CMP) process is now widely employed in the Integrated Circuit Fabrication. However, due to the complexity of process parameters on the material removal rate (MRR), mechanism of material removal and pattern effect are ...
Chun, Jung-Hoon   +3 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

MATERIAL REMOVAL RATE IN ELECTROCHEMICAL DISCHARGE MACHINING OF SMALL DIAMETER HOLES

open access: yesNonconventional Technologies Review, 2015
Electrochemical discharge machining method is based on the material removal from workpiece as a consequence of simultaneous development of electrical discharges between the electrodes and of the electrochemical reactions between the work liquid and ...
Margareta Coteata   +4 more
doaj  

STUDY OF POLISHING AISI 316L WITH STRUCTURED ABRASIVE [PDF]

open access: yesAnnals: Series on engineering sciences (Academy of Romanian Scientists), 2015
Finishing process like polishing is usually used to obtain high quality mechanical surface characteristics such as texture and roughness. These operations are mainly handmade and need highly trained operators thus limiting their repeatability and ...
François GOOSSENS   +2 more
doaj  

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