Results 111 to 120 of about 13,024,848 (326)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Study on Material Removal Rate in EDM Of 9XC Steel

International Journal of Mechanical Engineering
The present work examines the effects of discharge current (𝐼𝑒) and ignition voltage (𝑈𝑧) on the rate of material removal (MRR, denoted as 𝑄) during EDM of 9XC alloy tool steel, a very high-hardness tool steel used for mould manufacturing. In this article, a 22 full factorial design was used to systematically study the effects of process variables on a
Vinh-Binh Bui, Xuan-Thao Dang, Hong-Son Nguyen, Nhu-Uyen Vo Thi   +3 more
openaire   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Biological excess phosphorus removal in activated sludge systems [PDF]

, 1988
Includes bibliographies.When this investigation was commenced in 1983 two activated sludge systems had been developed in South Africa that accomplish biological excess phosphorus (P) removal, the UCT and modified Bardenpho systems.
Wentzel, Mark Charles
core   +1 more source

Advanced Optimization of Surface Characteristics and Material Removal Rate for Biocompatible Ti6Al4V Using WEDM Process with BBD and NSGA II. [PDF]

Materials (Basel), 2023
Nagadeepan A, Jayaprakash G, Senthilkumar V.   +2 more
europepmc   +1 more source

Influence of particle effects on the material removal rate utilizing electrokinetic phenomenon

, 2009
With the demand for precise nanometric material removal with minimal defects, several non-contact ultraprecision machining techniques were developed over recent decades.
Danyluk, S., Leo, C. S., Ng, S. H., Yang, C., Blackburn, T. L., Butler, D. L.; id_orcid   +5 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MUITI-OBJECTIVE OPTIMAZATION IN THE ELECTRICAL DISCHARGE MACHINING OF THE TA7 BASED ON BSO ALGORITHM

Jixie qiangdu, 2018
For the existing EDM machine,there is no specification of titanium alloy processing standard,the design center combination experiment,comprehensive consideration of no-load voltage,peak current,pulse width and pulse interval on TA7 EDM material removal ...
ZHANG LiXin, YANG Kang, LI YuXi
doaj  

Semi-Supervised Deep Kernel Active Learning for Material Removal Rate Prediction in Chemical Mechanical Planarization. [PDF]

Sensors (Basel), 2023
Lv C, Huang J, Zhang M, Wang H, Zhang T.
europepmc   +1 more source