Results 111 to 120 of about 541,541 (258)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Neuro-fuzzy techniques for modeling process parameters in pulsed electrochemical machining of steel

Nova Scientia
Pulsed Electrochemical Machining (PECM) is an advanced manufacturing method used in the metalworking industry to manufacture metal tools or components utilizing the principle of electrolysis.
Irvin Uriel Nopalera Angeles, Everardo Efrén Granda Gutiérrez, Roberto Alejo Eleuterio, René Arnulfo García Hernández, Ángel Hernández Castañeda, María Guadalupe Pineda Arizmendi   +5 more
doaj   +1 more source

Model of ELID Grinding Material Removal Rate [PDF]

Advances in Physics Research, 2014
openaire   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Effect of Lapping Parameters on Material Removal Rate and Surface Roughness of GaN (0001) Plane

Crystals
As a critical pretreatment process for chemical and mechanical polishing (CMP), the lapping roughness of gallium nitride (GaN) crystals directly influences the outcome of subsequent polishing and the reliability of final devices.
Hao Zhou, Yongliang Shao, Baoguo Zhang, Haixiao Hu, Yongzhong Wu, Xiaopeng Hao   +5 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Investigation of the Influence of Reduced Graphene Oxide Flakes in the Dielectric on Surface Characteristics and Material Removal Rate in EDM. [PDF]

Materials (Basel), 2019
Świercz R, Oniszczuk-Świercz D.
europepmc   +2 more sources

Optimization of process parameters for lapping quartz glass with fixed abrasive

Jin'gangshi yu moliao moju gongcheng, 2020
The material removal rate and the surface roughness were taken as indexes to evaluate quartz glass quality, and the rotating speed (A), the pressure (B) and the lapping slurry type (C) as the influencing factors were studied in the orthogonal test of ...
WANG Zhankui, YANG Yakun, PANG Minghua, MA Lijie, LIANG Mingchao, LI Yongfeng, SU Jianxiu   +6 more
doaj  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source