Results 111 to 120 of about 555,198 (301)

Experimental Study on Material Removal Rate for Engineering Ceramics Machining with Micro-Detonation of Striking Arc [PDF]

open access: yes, 2011
The material removal rate (MRR) of micro-detonation of striking arc machining (MDSAM) is studied. The orthogonal experimental design and regression analysis method are employed to build the empirical model and the influencing laws of processing ...
Ke Ling Lin   +4 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Modeling the Material Removal Rate in Micro Abrasive Water Jet Machining of Glasses [PDF]

open access: yes, 2010
Micro abrasive water jet (MAWJ) machining is a new promising micro machining technology for brittle material. The rate of material removal is one of the most important parameter for abrasive processes.
Jun Wang, Jing Ming Fan, Chang Ming Fan
core   +1 more source

Statistical Modeling and Optimization of Ra and Mrr in Ultrasonic - Assisted of 90CrSi Steel Using Graphite Electrodes

open access: yesJournal of Machine Engineering
This study investigates the modeling and single-objective optimization of surface roughness (Ra) and material removal rate (MRR) in electrical discharge machining (EDM) of external cylindrical surfaces of hardened 90CrSi tool steel. The machining process
Thanh Van Dinh   +4 more
doaj   +1 more source

Relationship between polishing performance and viscoelasticity of epoxy resin polishing pads

open access: yesNihon Kikai Gakkai ronbunshu, 2014
Polishing performances of glass using epoxy resin polishing pads from the aspect of their mechanical properties are described. Material removal rates are independent to the hardness of the epoxy resin pads.
Junji MURATA   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

MUITI-OBJECTIVE OPTIMAZATION IN THE ELECTRICAL DISCHARGE MACHINING OF THE TA7 BASED ON BSO ALGORITHM

open access: yesJixie qiangdu, 2018
For the existing EDM machine,there is no specification of titanium alloy processing standard,the design center combination experiment,comprehensive consideration of no-load voltage,peak current,pulse width and pulse interval on TA7 EDM material removal ...
ZHANG LiXin, YANG Kang, LI YuXi
doaj  

The Effect of Voltage on Material Removal Rate in the ECM Process

open access: yesEngineering, Technology & Applied Science Research
The development of machining processes, such as Electrochemical Machining (ECM), has improved manufacturing complex shapes and complicated materials. This research investigates the enhancement of the ECM process to achieve the highest quality of materials.
Nagham Ghanim Ghazi   +2 more
openaire   +1 more source

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