Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Effect of Contributing Parameters over Material Removal Rate in Machining Incoloy 825 using Electric Discharge Machining EDM [PDF]
, 2017 Manufacturers of modern era aim on improved quality at low cost. The production rate is one of the major contributors to the cost of the product which depends upon machining time. The work concentrates on obtaining the influential parameters for material
Vignesh Kumar S +3 more
core +1 more source
Advanced Optimization of Surface Characteristics and Material Removal Rate for Biocompatible Ti6Al4V Using WEDM Process with BBD and NSGA II. [PDF]
Materials (Basel), 2023 Nagadeepan A +2 more
europepmc +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Specific material removal rate of generating grinding of gears - a new model for the specific material removal rate of generating grinding of gears [PDF]
, 2022 S.360-367Zur Prozessanalyse und -auslegung kommt in der Schleiftechnik oft das bezogene Zeitspanvolumen als Prozesskenngröße zum Einsatz. Diese Kenngröße sollte beim kontinuierlichen Wälzschleifen von Schrägverzahnungen insbesondere an den lokalen ...
Westkämper, Engelbert +3 more
core
Semi-Supervised Deep Kernel Active Learning for Material Removal Rate Prediction in Chemical Mechanical Planarization. [PDF]
Sensors (Basel), 2023 Lv C, Huang J, Zhang M, Wang H, Zhang T.
europepmc +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Optimization and Modeling of Material Removal Rate in Wire-EDM of Silicon Particle Reinforced Al6061 Composite. [PDF]
Materials (Basel), 2021 Doreswamy D +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Neuro-fuzzy techniques for modeling process parameters in pulsed electrochemical machining of steel
Nova ScientiaPulsed Electrochemical Machining (PECM) is an advanced manufacturing method used in the metalworking industry to manufacture metal tools or components utilizing the principle of electrolysis.
Irvin Uriel Nopalera Angeles +5 more
doaj +1 more source