Results 121 to 130 of about 3,143,235 (349)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Relationship between polishing performance and viscoelasticity of epoxy resin polishing pads

Nihon Kikai Gakkai ronbunshu, 2014
Polishing performances of glass using epoxy resin polishing pads from the aspect of their mechanical properties are described. Material removal rates are independent to the hardness of the epoxy resin pads.
Junji MURATA, Motomu INAZAWA, Yasuhiro TANI, Yu ZHANG   +3 more
doaj   +1 more source

Study on Material Removal Rate of EDM in Deionized Water

Journal of The Japan Society of Electrical Machining Engineers, 1999
This paper describes that the material removal rate of the electrical discharge machining (EDM) is higher when deionized water is used as the working fluid than when EDM working oil is used. Influences of the electrode surface temperature, discharge energy distribution, carbon precipitation on anode surface, electrolysis, and reaction of oxidation on ...
Zhanbo YU, Masanori KUNIEDA
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Optimization Of Material Removal Rate And Surface Roughness Using The Taguchi Method [PDF]

, 2008
A non-conventional hybrid machining method called electrical discharge turning (EDT) process is optimized in this research. The EDT process is a suitable method to produce small components with cylindrical geometries.
Matoorian, Pooria
core  

Performance of Monolayer Graphene Nanomechanical Resonators with Electrical Readout

, 2009
The enormous stiffness and low density of graphene make it an ideal material for nanoelectromechanical (NEMS) applications. We demonstrate fabrication and electrical readout of monolayer graphene resonators, and test their response to changes in mass and
A Huttel, AB Hutchinson, AC Ferrari, B Lassagne, B Witkamp, BI Yakobson, C Lee, CD Dimitrakopoulos, Changyao Chen, D Garcia-Sanchez, E Stolyarova, F Schedin, HJ Mamin, Horst L. Stormer, HWC Postma, HY Chiu, I Bargatin, I Meric, Ioannis Kymissis, J Atalaya, J Moser, James Hone, JS Bunch, JS Bunch, K Jensen, KI Bolotin, Kirill I. Bolotin, KL Ekinci, KS Novoselov, M Ishigami, MD LaHaye, MY Han, MY Huang, N Mohanty, N Mounet, P Blake, P Mohanty, Philip Kim, RA Suleimanov, RG Knobel, S Evoy, Sami Rosenblatt, SC Jun, TMG Mohiuddin, Tony F. Heinz, V Sazonova, W Bao, William Kalb, YT Yang   +48 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

MUITI-OBJECTIVE OPTIMAZATION IN THE ELECTRICAL DISCHARGE MACHINING OF THE TA7 BASED ON BSO ALGORITHM

Jixie qiangdu, 2018
For the existing EDM machine,there is no specification of titanium alloy processing standard,the design center combination experiment,comprehensive consideration of no-load voltage,peak current,pulse width and pulse interval on TA7 EDM material removal ...
ZHANG LiXin, YANG Kang, LI YuXi
doaj