Results 141 to 150 of about 555,198 (301)

Efficient Cnc Milling By Adjusting Material Removal Rate

, 2011
This paper describes a combined mathematicalgraphical approach for optimum tool path planning in order to improve machining efficiency. A methodology has been used that stabilizes machining operations by adjusting material removal rate in pocket milling operations while keeping cutting forces within limits.
openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Strain rate dependent material removal mechanism and surface morphology formation mechanism for high strength CFRTP

Materials & Design
Machining quality and efficiency are vital for the high-performance assembly of high strength CFRTP components. Strain rate sensitivity of thermoplastic matrix results in complex machining mechanism under the wide range of cutting speed.
Kuangqing Hu, Shunuan Liu, Shiming Liang, Bin Luo, Kaifu Zhang   +4 more
doaj   +1 more source

Model of ELID Grinding Material Removal Rate [PDF]

Advances in Physics Research, 2014
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The effect of alternative detergent builders on the nutrient removal activated sludge sewage treatment process [PDF]

, 1993
Includes bibliography.Phosphate is an essential nutrient for photosynthetic plant growth. However if over-supplied in a water body, it leads to excessive algal growth, a condition is termed eutrophication.
Kaschula, Wendy A
core  

MODELING ANALYSIS AND EXPERIMENTAL RESEARCH OF THE MATERIAL REMOVAL RATE OF THE MONOCRYSTALLINE SILICON IN THE COURSE OF THE ELETRICAL DISCHARGE MACHINING

Jixie qiangdu, 2017
Based on the feasibility of the discharge machining of the semiconductor material,it analyze several major factors which influences the material removal rate,including the open circuit voltage,peak current,pulse width and pulse interval.Using central ...
XIN Bin, LI ShuJuan, LU Xiong, DONG YongHeng, SHI WeiChao   +4 more
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Multistage and multiple biomass approaches to efficient biological nitrogen removal using biofilm cultures [PDF]

, 2008
Nitrogen removal from wastewater is important for the revention of significant health and environmental impacts such as eutrophication. Nitrogen removal is achieved by the combined action of nitrification and denitrification.
Hughes, Leonie
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source