Results 71 to 80 of about 13,024,848 (326)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Study-from-microcosms-and-mesocosms-of-Escherichia-coli-removal-in-high-rate-algae-ponds

, 2021
This repository contains the Matlab code used in the development of the manuscript "Study from microcosms and mesocosms reveals Escherichia coli removal in high rate algae ponds is primarily caused by dark decay"The scripts contained in this folder ...
Paul Chambonniere (11886674)
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Evaluation and improvement of material removal rate with good surface quality in TC4 blisk blade polishing process

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2018
As a kind of efficient and rapid developed surface processing technique, polishing technology is widely used to improve the surface quality in the precision manufacturing of aero-engine blisk blades. Since blisk blade polishing is a metal removal process
Zhen CHEN, Yaoyao SHI, Xiaojun LIN
doaj   +1 more source

Fixed Abrasive Polishing in an Anhydrous Environment: A Material Removal Model for Fused Silica

Machines, 2022
Due to the prevalent randomness and uncertainties associated with traditional loose polishing, fixed abrasive polishing in an anhydrous environment has been chosen as a new polishing method. In this paper, cerium oxide is the main component for polishing
Yuan Qian, Wei Yang, Chaoxu Chen, Xiaoluo Yu   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Optimization of processing parameters during electrical discharge diamond grindingof RB-SiC ceramics based on grey relational theory

Jin'gangshi yu moliao moju gongcheng, 2021
The electrical discharge diamond grinding tests of RB-SiC ceramics were performed. The influence of wheel parameters, grinding parameters and discharge parameters on surface roughness, material removal rate, wheel wear rate and normal grinding force were
HUANG Shuqiang, WEI Zongze, RAO Xiaoshuang, LI Chen, ZHANG Feihu   +4 more
doaj  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Optimization of material removal rate in milling of thin-walled structures using penalty cost function

International journal of machine tools & manufacture, 2019
The high flexibility of thin-walled structures makes their machining process prone to chatter and excessive vibrations. This challenge is compounded by the continuous varying dynamics of the workpiece as material is removed from the workpiece.
Kasper Ringgaard, Y. Mohammadi, C. Merrild, O. Balling, K. Ahmadi   +4 more
semanticscholar   +1 more source