Results 71 to 80 of about 3,143,235 (349)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
An Experimental Investigation of Hot Machining with Induction to Improve Ti-5553 Machinability [PDF]
, 2011 The manufacturing of aeronautic parts with high mechanical properties requires the use of high performance materials. That’s why; new materials are used for landing gears such as the titanium alloy Ti-5553.
Baili, Maher +4 more
core +3 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Manufacturing Review, 2021 The selection of optimal process parameters is essential while machining thin-wall parts since it influences the quality of the product and affects productivity.
Bolar Gururaj +1 more
doaj +1 more source
Kinematical and mechanical aspects of wafer slicing [PDF]
, 1982 Some recently achieved results concerning the technological fundamentals of slurry sawing are presented. The specific material removal process and the related kinematic and geometric contact conditions between workpiece and saw blade are described.
Werner, P. G.
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Parameters Optimization for Electropolishing Titanium by Using Taguchi-Based Pareto ANOVA
Metals, 2023 Material removal rate in electropolishing is often overlooked because this process generally addressed for surface finish; however, it is paramount on metallic sheet machining possessed with intricate geometry.
Gunawan Setia Prihandana +5 more
doaj +1 more source
Feasibility investigation of direct laser cutting process of metal foam with high pore density [PDF]
, 2018 To avoid damage to the pore structure of metal foam, a laser cutting process for efficiently and directly cutting metal foam into regular shapes is proposed.
AC Kaya +37 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Analysis on mechanism of material removal rate and surface flow machining process [PDF]
MATEC Web of ConferencesA novel finishing technique called abrasive flow machining (AFM) uses abrasive particles as the instrument for material removal. The term "self-deformable stone" refers to the abrasive particle-containing carrier medium, and AFM is commonly known as "no ...
Kondala Rao Peram, Ranga Janardhana G.
doaj +1 more source