Results 141 to 150 of about 1,850,501 (264)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Vinyl chloride oligomers: On the road to understand the potential toxicity of PVC nanoplastics. [PDF]

PLoS One
Quevedo E, Perez-Sanchez E, Caballero A, Martínez A.   +3 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Tailoring $\pi {\text{--}}d$ Magnetic Interactions in Metallated Porphyrin Nanotapes. [PDF]

Angew Chem Int Ed Engl
Robles R, Edalatmanesh S, Sun Q, Ruffieux P, Fasel R, Mateo LM, Bottari G, Torres T, Lorente N.   +8 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Thermal Insulation and Compressive Strength of Lightweight Geopolymer Foam Concrete Exposed to Accelerated Weathering by Carbonation, Salt Fog and UV Light. [PDF]

Materials (Basel)
de la Rosa-Corral GA, Corral-Higuera R, Arredondo-Rea SP, Castro-Beltrán A, De la Cruz-Delgado A, Martinez-Garcia A, Orozco-Carmona VM.   +6 more
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

High-Capacity Adsorption of a Cationic Dye Using Alkali-Activated Geopolymers Derived from Agricultural Residues. [PDF]

Materials (Basel)
Hernández-Escobar CA, Mares-García AS, Orozco-Alvarado MA, Vega-Rios A, Piñón-Balderrama CI, Estrada-Monje A, Zaragoza-Contreras EA.   +6 more
europepmc   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Accurate and Fast Thermal Sensing via Phase-Responsive Nanothermometers and Neural Networks. [PDF]

Nano Lett
París-Ogáyar M, Ming L, Zhang F, Ximendes E, Marin R, Lifante-Pedrola G, Serrano A, Espinosa A, Haro-González P, Hernando J, Ruiz-Molina D, Otaegui JR, Roscini C, Jaque D.   +13 more
europepmc   +1 more source